Therapeutic Applications for Adipose-Derived Stem Cells in Wound Healing and Tissue Engineering

Michelle E. McCarthy, Theodore A. Brown, Joanna Bukowska, Bruce A. Bunnell, Trivia Frazier, Xiying Wu, Jeffrey M. Gimble

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Purpose of Review: The use of adipose-derived stem cells (ASCs) has garnered recent interest for their accessibility and potential utility in wound healing applications. The purpose of this review is to provide an overview of developments within the last 5 years regarding therapeutic use of ASCs in wound healing applications. Recent Findings: Recent studies have demonstrated that ASCs do not exert the majority of their effects through differentiation, as previously believed. Rather, when they improve healing, it is via secreted factors that promote vascularization and control inflammation. New therapeutic approaches reflect this shift in belief. Summary: ASC-based therapies can improve outcomes in the treatment of a variety of wound types. Questions about how to best implement ASCs in the clinical setting remain, and their answers will profoundly influence the utility and availability of ASC-based therapies.

Original languageEnglish
Pages (from-to)127-137
Number of pages11
JournalCurrent Stem Cell Reports
Volume4
Issue number2
DOIs
StatePublished - 1 Jun 2018

Keywords

  • Adipose-derived stem cells
  • Cytokine
  • Pressure ulcers
  • Scaffold
  • Skin wound healing
  • Stromal vascular fraction

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