@article{217e84c1a42a4c8186a0705a6c93b2c8,
title = "Therapeutic Applications for Adipose-Derived Stem Cells in Wound Healing and Tissue Engineering",
abstract = "Purpose of Review: The use of adipose-derived stem cells (ASCs) has garnered recent interest for their accessibility and potential utility in wound healing applications. The purpose of this review is to provide an overview of developments within the last 5 years regarding therapeutic use of ASCs in wound healing applications. Recent Findings: Recent studies have demonstrated that ASCs do not exert the majority of their effects through differentiation, as previously believed. Rather, when they improve healing, it is via secreted factors that promote vascularization and control inflammation. New therapeutic approaches reflect this shift in belief. Summary: ASC-based therapies can improve outcomes in the treatment of a variety of wound types. Questions about how to best implement ASCs in the clinical setting remain, and their answers will profoundly influence the utility and availability of ASC-based therapies.",
keywords = "Adipose-derived stem cells, Cytokine, Pressure ulcers, Scaffold, Skin wound healing, Stromal vascular fraction",
author = "McCarthy, {Michelle E.} and Brown, {Theodore A.} and Joanna Bukowska and Bunnell, {Bruce A.} and Trivia Frazier and Xiying Wu and Gimble, {Jeffrey M.}",
note = "Funding Information: The authors wish to thank Dr. Barbara Gawronska-Kozak, the staff of LaCell LLC, and the members of the Center for Stem Cell Research and Regenerative Medicine at Tulane University for their input and discussions during the preparation of this review article. This article is part of the Topical Collection on Artificial Tissues J.M.G. and X.W. are co-founders, co-owners and Chief Scientific Officer and Vice President for Research and Development, respectively, of LaCell LLC, a biotechnology company focusing on the clinical translation of stromal-cell and stem-cell science. J.M.G., X.W., and T.F. are the co-founders and co-owners of Obatala Sciences Inc., a biotechnology company focusing on humanized “fat on a chip” as a product for drug discovery where T.F. serves as the President and Chief Executive Officer. J.M.G. is an inventor on multiple patents relating to adipose cells and products. X.W is about to submit a patent application from LaCell LLC on the use of adipose cells in therapy. The other authors declare no competing interests. Publisher Copyright: {\textcopyright} 2018, Springer International Publishing AG, part of Springer Nature.",
year = "2018",
month = jun,
day = "1",
doi = "10.1007/s40778-018-0125-9",
language = "English",
volume = "4",
pages = "127--137",
journal = "Current Stem Cell Reports",
issn = "2198-7866",
publisher = "Springer International Publishing AG",
number = "2",
}