The unique protein kinase Cη: Implications for breast cancer (Review)

Deepanwita Pal, Alakananda Basu

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Deregulation of key signal transduction pathways that govern important cellular processes leads to cancer. The development of effective therapeutics for cancer warrants a comprehensive understanding of the signaling pathways that are deregulated in cancer. The protein kinase C (PKC) family has served as an attractive target for cancer therapy for decades owing to its crucial roles in several cellular processes. PKCη is a novel member of the PKC family that plays critical roles in various cellular processes such as growth, proliferation, differentiation and cell death. The regulation of PKCη appears to be unique compared to other PKC isozymes, and there are conflicting reports regarding its role in cancer. This review focuses on the unique aspects of PKCη in terms of its structure, regulation and subcellular distribution and speculates on how these features could account for its distinct functions. We have also discussed the functional implications of PKCη in cancer with particular emphasis on breast cancer.

Original languageEnglish
Pages (from-to)493-498
Number of pages6
JournalInternational journal of oncology
Volume45
Issue number2
DOIs
Publication statusPublished - Aug 2014

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Keywords

  • Breast cancer
  • Cellular regulation
  • Protein kinase C
  • Protein kinase Cη
  • Tumor promoters

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