TY - JOUR
T1 - The 'sweet' spot of cellular pluripotency
T2 - Protein glycosylation in human pluripotent stem cells and its applications in regenerative medicine
AU - Wang, Yu Chieh
AU - Lin, Victor
AU - Loring, Jeanne F.
AU - Peterson, Suzanne E.
N1 - Funding Information:
Y-C Wang is supported by the UNT Health Science Center (UNTHSC Start-up Fund for Stem Cell Laboratory). V Lin
Publisher Copyright:
© 2015 Informa UK, Ltd.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Introduction: Human pluripotent stem cells (hPSCs) promise for the future of regenerative medicine. The structural and biochemical diversity associated with glycans makes them a unique type of macromolecule modification that is involved in the regulation of a vast array of biochemical events and cellular activities including pluripotency in hPSCs. The primary focus of this review article is to highlight recent advances in stem cell research from a glycobiological perspective. We also discuss how our understanding of glycans and glycosylation may help overcome barriers hindering the clinical application of hPSC-derived cells.Areas covered: A literature survey using NCBI-PubMed and Google Scholar was performed in 2014.Expert opinion: Regenerative medicine hopes to provide novel strategies to combat human disease and tissue injury that currently lack effective therapies. Although progress in this field is accelerating, many critical issues remain to be addressed in order for cell-based therapy to become a practical and safe treatment option. Emerging evidence suggests that protein glycosylation may significantly influence the regulation of cellular pluripotency, and that the exploitation of protein glycosylation in hPSCs and their differentiated derivatives may lead to transformative and translational discoveries for regenerative medicine. In addition, hPSCs represent a novel research platform for investigating glycosylation-related disease.
AB - Introduction: Human pluripotent stem cells (hPSCs) promise for the future of regenerative medicine. The structural and biochemical diversity associated with glycans makes them a unique type of macromolecule modification that is involved in the regulation of a vast array of biochemical events and cellular activities including pluripotency in hPSCs. The primary focus of this review article is to highlight recent advances in stem cell research from a glycobiological perspective. We also discuss how our understanding of glycans and glycosylation may help overcome barriers hindering the clinical application of hPSC-derived cells.Areas covered: A literature survey using NCBI-PubMed and Google Scholar was performed in 2014.Expert opinion: Regenerative medicine hopes to provide novel strategies to combat human disease and tissue injury that currently lack effective therapies. Although progress in this field is accelerating, many critical issues remain to be addressed in order for cell-based therapy to become a practical and safe treatment option. Emerging evidence suggests that protein glycosylation may significantly influence the regulation of cellular pluripotency, and that the exploitation of protein glycosylation in hPSCs and their differentiated derivatives may lead to transformative and translational discoveries for regenerative medicine. In addition, hPSCs represent a novel research platform for investigating glycosylation-related disease.
KW - Glycans
KW - Human pluripotent stem cells
KW - Protein glycosylation
KW - Regenerative medicine
UR - http://www.scopus.com/inward/record.url?scp=84927617058&partnerID=8YFLogxK
U2 - 10.1517/14712598.2015.1021329
DO - 10.1517/14712598.2015.1021329
M3 - Review article
C2 - 25736263
AN - SCOPUS:84927617058
SN - 1471-2598
VL - 15
SP - 679
EP - 687
JO - Expert Opinion on Biological Therapy
JF - Expert Opinion on Biological Therapy
IS - 5
ER -