The 'sweet' spot of cellular pluripotency: Protein glycosylation in human pluripotent stem cells and its applications in regenerative medicine

Yu-Chieh Wang, Victor Lin, Jeanne F. Loring, Suzanne E. Peterson

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Introduction: Human pluripotent stem cells (hPSCs) promise for the future of regenerative medicine. The structural and biochemical diversity associated with glycans makes them a unique type of macromolecule modification that is involved in the regulation of a vast array of biochemical events and cellular activities including pluripotency in hPSCs. The primary focus of this review article is to highlight recent advances in stem cell research from a glycobiological perspective. We also discuss how our understanding of glycans and glycosylation may help overcome barriers hindering the clinical application of hPSC-derived cells.Areas covered: A literature survey using NCBI-PubMed and Google Scholar was performed in 2014.Expert opinion: Regenerative medicine hopes to provide novel strategies to combat human disease and tissue injury that currently lack effective therapies. Although progress in this field is accelerating, many critical issues remain to be addressed in order for cell-based therapy to become a practical and safe treatment option. Emerging evidence suggests that protein glycosylation may significantly influence the regulation of cellular pluripotency, and that the exploitation of protein glycosylation in hPSCs and their differentiated derivatives may lead to transformative and translational discoveries for regenerative medicine. In addition, hPSCs represent a novel research platform for investigating glycosylation-related disease.

Original languageEnglish
Pages (from-to)679-687
Number of pages9
JournalExpert Opinion on Biological Therapy
Volume15
Issue number5
DOIs
StatePublished - 1 Jan 2015

Fingerprint

Glycosylation
Pluripotent Stem Cells
Regenerative Medicine
Stem cells
Proteins
Polysaccharides
Stem Cell Research
Expert Testimony
Cell- and Tissue-Based Therapy
Macromolecules
PubMed
Tissue
Derivatives
Wounds and Injuries
Therapeutics
Research

Keywords

  • Glycans
  • Human pluripotent stem cells
  • Protein glycosylation
  • Regenerative medicine

Cite this

@article{dd8275b3e58145829a69a05650cd8586,
title = "The 'sweet' spot of cellular pluripotency: Protein glycosylation in human pluripotent stem cells and its applications in regenerative medicine",
abstract = "Introduction: Human pluripotent stem cells (hPSCs) promise for the future of regenerative medicine. The structural and biochemical diversity associated with glycans makes them a unique type of macromolecule modification that is involved in the regulation of a vast array of biochemical events and cellular activities including pluripotency in hPSCs. The primary focus of this review article is to highlight recent advances in stem cell research from a glycobiological perspective. We also discuss how our understanding of glycans and glycosylation may help overcome barriers hindering the clinical application of hPSC-derived cells.Areas covered: A literature survey using NCBI-PubMed and Google Scholar was performed in 2014.Expert opinion: Regenerative medicine hopes to provide novel strategies to combat human disease and tissue injury that currently lack effective therapies. Although progress in this field is accelerating, many critical issues remain to be addressed in order for cell-based therapy to become a practical and safe treatment option. Emerging evidence suggests that protein glycosylation may significantly influence the regulation of cellular pluripotency, and that the exploitation of protein glycosylation in hPSCs and their differentiated derivatives may lead to transformative and translational discoveries for regenerative medicine. In addition, hPSCs represent a novel research platform for investigating glycosylation-related disease.",
keywords = "Glycans, Human pluripotent stem cells, Protein glycosylation, Regenerative medicine",
author = "Yu-Chieh Wang and Victor Lin and Loring, {Jeanne F.} and Peterson, {Suzanne E.}",
year = "2015",
month = "1",
day = "1",
doi = "10.1517/14712598.2015.1021329",
language = "English",
volume = "15",
pages = "679--687",
journal = "Expert Opinion on Biological Therapy",
issn = "1471-2598",
publisher = "Taylor and Francis Ltd.",
number = "5",

}

The 'sweet' spot of cellular pluripotency : Protein glycosylation in human pluripotent stem cells and its applications in regenerative medicine. / Wang, Yu-Chieh; Lin, Victor; Loring, Jeanne F.; Peterson, Suzanne E.

In: Expert Opinion on Biological Therapy, Vol. 15, No. 5, 01.01.2015, p. 679-687.

Research output: Contribution to journalReview article

TY - JOUR

T1 - The 'sweet' spot of cellular pluripotency

T2 - Protein glycosylation in human pluripotent stem cells and its applications in regenerative medicine

AU - Wang, Yu-Chieh

AU - Lin, Victor

AU - Loring, Jeanne F.

AU - Peterson, Suzanne E.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Introduction: Human pluripotent stem cells (hPSCs) promise for the future of regenerative medicine. The structural and biochemical diversity associated with glycans makes them a unique type of macromolecule modification that is involved in the regulation of a vast array of biochemical events and cellular activities including pluripotency in hPSCs. The primary focus of this review article is to highlight recent advances in stem cell research from a glycobiological perspective. We also discuss how our understanding of glycans and glycosylation may help overcome barriers hindering the clinical application of hPSC-derived cells.Areas covered: A literature survey using NCBI-PubMed and Google Scholar was performed in 2014.Expert opinion: Regenerative medicine hopes to provide novel strategies to combat human disease and tissue injury that currently lack effective therapies. Although progress in this field is accelerating, many critical issues remain to be addressed in order for cell-based therapy to become a practical and safe treatment option. Emerging evidence suggests that protein glycosylation may significantly influence the regulation of cellular pluripotency, and that the exploitation of protein glycosylation in hPSCs and their differentiated derivatives may lead to transformative and translational discoveries for regenerative medicine. In addition, hPSCs represent a novel research platform for investigating glycosylation-related disease.

AB - Introduction: Human pluripotent stem cells (hPSCs) promise for the future of regenerative medicine. The structural and biochemical diversity associated with glycans makes them a unique type of macromolecule modification that is involved in the regulation of a vast array of biochemical events and cellular activities including pluripotency in hPSCs. The primary focus of this review article is to highlight recent advances in stem cell research from a glycobiological perspective. We also discuss how our understanding of glycans and glycosylation may help overcome barriers hindering the clinical application of hPSC-derived cells.Areas covered: A literature survey using NCBI-PubMed and Google Scholar was performed in 2014.Expert opinion: Regenerative medicine hopes to provide novel strategies to combat human disease and tissue injury that currently lack effective therapies. Although progress in this field is accelerating, many critical issues remain to be addressed in order for cell-based therapy to become a practical and safe treatment option. Emerging evidence suggests that protein glycosylation may significantly influence the regulation of cellular pluripotency, and that the exploitation of protein glycosylation in hPSCs and their differentiated derivatives may lead to transformative and translational discoveries for regenerative medicine. In addition, hPSCs represent a novel research platform for investigating glycosylation-related disease.

KW - Glycans

KW - Human pluripotent stem cells

KW - Protein glycosylation

KW - Regenerative medicine

UR - http://www.scopus.com/inward/record.url?scp=84927617058&partnerID=8YFLogxK

U2 - 10.1517/14712598.2015.1021329

DO - 10.1517/14712598.2015.1021329

M3 - Review article

C2 - 25736263

AN - SCOPUS:84927617058

VL - 15

SP - 679

EP - 687

JO - Expert Opinion on Biological Therapy

JF - Expert Opinion on Biological Therapy

SN - 1471-2598

IS - 5

ER -