TY - JOUR
T1 - The SRY-1532 site of the human Y chromosome is subject to recurrent single nucleotide mutations
AU - Ramana, G.
AU - Singh, L.
AU - Chakraborty, R.
PY - 2001
Y1 - 2001
N2 - Haplotype determination based on three Y-linked polymorphic sites, 92R7 (C/T), SRY-1532 (A/G), and YAP (-/+), in 127 males belonging to three caste Hindu populations of South India (Vizag Brahmins, Peruru Brahmins, and Kammas) and 13 males belonging to a migrant group (the Siddis) showed the existence of all four haplotypes (CA-, CG-, TG-, and TA-) under the YAP- background. This finding suggests that the reverse mutation (G → A) at the SRY-1532 site, described earlier in the literature, is present in South Indian populations as well. The YAP+ mutation was seen in only five Siddi individuals. Four of these were of the CG+ haplotype structure, but a novel haplotype (CA+) was found in one male. To explain the occurrence of the six haplotypes found within these three sites, a haplotype tree is constructed that introduces a new reverse mutation at the SRY-1532 site (G → A), occurring under the CG+ background after the migrant Siddi population arrived in India.
AB - Haplotype determination based on three Y-linked polymorphic sites, 92R7 (C/T), SRY-1532 (A/G), and YAP (-/+), in 127 males belonging to three caste Hindu populations of South India (Vizag Brahmins, Peruru Brahmins, and Kammas) and 13 males belonging to a migrant group (the Siddis) showed the existence of all four haplotypes (CA-, CG-, TG-, and TA-) under the YAP- background. This finding suggests that the reverse mutation (G → A) at the SRY-1532 site, described earlier in the literature, is present in South Indian populations as well. The YAP+ mutation was seen in only five Siddi individuals. Four of these were of the CG+ haplotype structure, but a novel haplotype (CA+) was found in one male. To explain the occurrence of the six haplotypes found within these three sites, a haplotype tree is constructed that introduces a new reverse mutation at the SRY-1532 site (G → A), occurring under the CG+ background after the migrant Siddi population arrived in India.
KW - Hindu Populations
KW - India
KW - Siddis
KW - Y-Chromosome Haplotypes
UR - http://www.scopus.com/inward/record.url?scp=0035059480&partnerID=8YFLogxK
U2 - 10.1353/hub.2001.0010
DO - 10.1353/hub.2001.0010
M3 - Article
C2 - 11332646
AN - SCOPUS:0035059480
SN - 0018-7143
VL - 73
SP - 71
EP - 80
JO - Human Biology
JF - Human Biology
IS - 1
ER -