The spatial distribution of actin and mechanical cycle of myosin are different in right and left ventricles of healthy mouse hearts

J. Nagwekar, D. Duggal, R. Rich, Sangram Limbaji Raut, Rafal Fudala, Ignacy Gryczynski, Zygmunt Gryczynski, Julian Borejdo

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

The contraction of the right ventricle (RV) expels blood into the pulmonary circulation, and the contraction of the left ventricle (LV) pumps blood into the systemic circulation through the aorta. The respective afterloads imposed on the LV and RV by aortic and pulmonary artery pressures create very different mechanical requirements for the two ventricles. Indeed, differences have been observed in the contractile performance between left and right ventricular myocytes in dilated cardiomyopathy, in congestive heart failure, and in energy usage and speed of contraction at light loads in healthy hearts. In spite of these functional differences, it is commonly believed that the right and left ventricular muscles are identical because there were no differences in stress development, twitch duration, work performance, or power among the RV and LV in dogs. This report shows that on a mesoscopic scale [when only a few molecules are studied (here three to six molecules of actin) in ex vivo ventricular myofibrils], the two ventricles in rigor differ in the degree of orientational disorder of actin within in filaments and during contraction in the kinetics of the cross-bridge cycle.

Original languageEnglish
Pages (from-to)7641-7649
Number of pages9
JournalBiochemistry
Volume53
Issue number48
DOIs
StatePublished - 9 Dec 2014

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Myosins
Spatial distribution
Heart Ventricles
Actins
Blood
Molecules
Muscle
Pulmonary Circulation
Myofibrils
Dilated Cardiomyopathy
Pumps
Muscle Cells
Pulmonary Artery
Kinetics
Aorta
Heart Failure
Dogs
Pressure
Muscles

Cite this

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title = "The spatial distribution of actin and mechanical cycle of myosin are different in right and left ventricles of healthy mouse hearts",
abstract = "The contraction of the right ventricle (RV) expels blood into the pulmonary circulation, and the contraction of the left ventricle (LV) pumps blood into the systemic circulation through the aorta. The respective afterloads imposed on the LV and RV by aortic and pulmonary artery pressures create very different mechanical requirements for the two ventricles. Indeed, differences have been observed in the contractile performance between left and right ventricular myocytes in dilated cardiomyopathy, in congestive heart failure, and in energy usage and speed of contraction at light loads in healthy hearts. In spite of these functional differences, it is commonly believed that the right and left ventricular muscles are identical because there were no differences in stress development, twitch duration, work performance, or power among the RV and LV in dogs. This report shows that on a mesoscopic scale [when only a few molecules are studied (here three to six molecules of actin) in ex vivo ventricular myofibrils], the two ventricles in rigor differ in the degree of orientational disorder of actin within in filaments and during contraction in the kinetics of the cross-bridge cycle.",
author = "J. Nagwekar and D. Duggal and R. Rich and Raut, {Sangram Limbaji} and Rafal Fudala and Ignacy Gryczynski and Zygmunt Gryczynski and Julian Borejdo",
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The spatial distribution of actin and mechanical cycle of myosin are different in right and left ventricles of healthy mouse hearts. / Nagwekar, J.; Duggal, D.; Rich, R.; Raut, Sangram Limbaji; Fudala, Rafal; Gryczynski, Ignacy; Gryczynski, Zygmunt; Borejdo, Julian.

In: Biochemistry, Vol. 53, No. 48, 09.12.2014, p. 7641-7649.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - The spatial distribution of actin and mechanical cycle of myosin are different in right and left ventricles of healthy mouse hearts

AU - Nagwekar, J.

AU - Duggal, D.

AU - Rich, R.

AU - Raut, Sangram Limbaji

AU - Fudala, Rafal

AU - Gryczynski, Ignacy

AU - Gryczynski, Zygmunt

AU - Borejdo, Julian

PY - 2014/12/9

Y1 - 2014/12/9

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