The rostral and caudal ventrolateral medulla in young spontaneously hypertensive rats

J. Kevin Smith; Kirk W. Barron

doi:10.1016/0006-8993(90)91213-Z

The rostral and caudal ventrolateral medulla in young spontaneously hypertensive rats

J. Kevin Smith, Kirk W. Barron

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Abstract

This study was designed to compare the cardiovascular influences of the rostral ventrolateral medulla (RVLM) and the caudal ventrolateral medulla (CVLM) in young (5-6 weeks) spontaneously hypertensive (SH) and normotensive Wistar-Kyoto (WKY) rats. SH and WKY groups had similar pressor and depressor responses to microinjection of l-glutamate into the RVLM and the CVLM, respectively. In addition the results of this study indicate a reduced tonic sympathoinhibitory function of the CVLM in young SH rats, which may contribute to the development of hypertension in the spontaneously hypertensive rat.

Original language	English
Pages (from-to)	153-158
Number of pages	6
Journal	Brain Research
Volume	506
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(90)91213-Z
State	Published - 1 Jan 1990

Keywords

Cardiovascular effect
Heart rate
Hypertension
Mean arterial pressure
Spontaneously hypertensive rat
Tetrodotoxin
Ventrolateral medulla
Wistar-Kyoto rat
l-Glutamate

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10.1016/0006-8993(90)91213-Z

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abstract = "This study was designed to compare the cardiovascular influences of the rostral ventrolateral medulla (RVLM) and the caudal ventrolateral medulla (CVLM) in young (5-6 weeks) spontaneously hypertensive (SH) and normotensive Wistar-Kyoto (WKY) rats. SH and WKY groups had similar pressor and depressor responses to microinjection of l-glutamate into the RVLM and the CVLM, respectively. In addition the results of this study indicate a reduced tonic sympathoinhibitory function of the CVLM in young SH rats, which may contribute to the development of hypertension in the spontaneously hypertensive rat.",

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AB - This study was designed to compare the cardiovascular influences of the rostral ventrolateral medulla (RVLM) and the caudal ventrolateral medulla (CVLM) in young (5-6 weeks) spontaneously hypertensive (SH) and normotensive Wistar-Kyoto (WKY) rats. SH and WKY groups had similar pressor and depressor responses to microinjection of l-glutamate into the RVLM and the CVLM, respectively. In addition the results of this study indicate a reduced tonic sympathoinhibitory function of the CVLM in young SH rats, which may contribute to the development of hypertension in the spontaneously hypertensive rat.

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KW - Mean arterial pressure

KW - Spontaneously hypertensive rat

KW - Tetrodotoxin

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The rostral and caudal ventrolateral medulla in young spontaneously hypertensive rats

Abstract

Keywords

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