Abstract
This study was designed to compare the cardiovascular influences of the rostral ventrolateral medulla (RVLM) and the caudal ventrolateral medulla (CVLM) in young (5-6 weeks) spontaneously hypertensive (SH) and normotensive Wistar-Kyoto (WKY) rats. SH and WKY groups had similar pressor and depressor responses to microinjection of l-glutamate into the RVLM and the CVLM, respectively. In addition the results of this study indicate a reduced tonic sympathoinhibitory function of the CVLM in young SH rats, which may contribute to the development of hypertension in the spontaneously hypertensive rat.
Original language | English |
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Pages (from-to) | 153-158 |
Number of pages | 6 |
Journal | Brain Research |
Volume | 506 |
Issue number | 1 |
DOIs | |
State | Published - 1 Jan 1990 |
Keywords
- Cardiovascular effect
- Heart rate
- Hypertension
- Mean arterial pressure
- Spontaneously hypertensive rat
- Tetrodotoxin
- Ventrolateral medulla
- Wistar-Kyoto rat
- l-Glutamate