The rostral and caudal ventrolateral medulla in young spontaneously hypertensive rats

J. Kevin Smith, Kirk W. Barron

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Abstract

This study was designed to compare the cardiovascular influences of the rostral ventrolateral medulla (RVLM) and the caudal ventrolateral medulla (CVLM) in young (5-6 weeks) spontaneously hypertensive (SH) and normotensive Wistar-Kyoto (WKY) rats. SH and WKY groups had similar pressor and depressor responses to microinjection of l-glutamate into the RVLM and the CVLM, respectively. In addition the results of this study indicate a reduced tonic sympathoinhibitory function of the CVLM in young SH rats, which may contribute to the development of hypertension in the spontaneously hypertensive rat.

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalBrain Research
Volume506
Issue number1
DOIs
StatePublished - 1 Jan 1990

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Keywords

  • Cardiovascular effect
  • Heart rate
  • Hypertension
  • Mean arterial pressure
  • Spontaneously hypertensive rat
  • Tetrodotoxin
  • Ventrolateral medulla
  • Wistar-Kyoto rat
  • l-Glutamate

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