TY - JOUR
T1 - The role of CD8 T cells in innate immunity and in antigen non-specific protection
AU - Berg, Rance E.
AU - Forman, James
N1 - Funding Information:
This work was supported in part by National Institutes of Health grants AI064592 (RB) and AI45764 (JF).
PY - 2006/6
Y1 - 2006/6
N2 - The role of CD8 T cells in adaptive immune responses is well understood. These lymphocytes respond through their T cell receptors to diverse antigens presented by MHC class I molecules by proliferating, secreting cytokines and chemokines, and directly lysing infected cells. Recently, a role for CD8 T cells in the innate immune response has become apparent. Independent of T cell receptor ligation, CD8 T cells can mount a response against pathogens by secreting cytokines and can defend against tumors by directly killing transformed cells. This innate response has been shown to be beneficial in controlling several types of bacterial infections. However, a subset of CD8 T cells that have innate non-antigen-specific capabilities has been implicated in self-reactivity, which could lead to autoimmunity.
AB - The role of CD8 T cells in adaptive immune responses is well understood. These lymphocytes respond through their T cell receptors to diverse antigens presented by MHC class I molecules by proliferating, secreting cytokines and chemokines, and directly lysing infected cells. Recently, a role for CD8 T cells in the innate immune response has become apparent. Independent of T cell receptor ligation, CD8 T cells can mount a response against pathogens by secreting cytokines and can defend against tumors by directly killing transformed cells. This innate response has been shown to be beneficial in controlling several types of bacterial infections. However, a subset of CD8 T cells that have innate non-antigen-specific capabilities has been implicated in self-reactivity, which could lead to autoimmunity.
UR - http://www.scopus.com/inward/record.url?scp=33646151650&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2006.03.010
DO - 10.1016/j.coi.2006.03.010
M3 - Review article
C2 - 16616476
AN - SCOPUS:33646151650
SN - 0952-7915
VL - 18
SP - 338
EP - 343
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 3
ER -