The relationship of serum IgA concentration to human immunodeficiency virus (HIV) infection: A cross-sectional study of HIV-seropositive individuals detected by screening in the United States Air Force

John A. Fling; Joseph R. Fischer; R. Neal Boswell; Michael J. Reid

doi:10.1016/0091-6749(88)90132-7

The relationship of serum IgA concentration to human immunodeficiency virus (HIV) infection: A cross-sectional study of HIV-seropositive individuals detected by screening in the United States Air Force

John A. Fling, Joseph R. Fischer, R. Neal Boswell, Michael J. Reid

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Serum immunoglobulins were measured in 107 patients with human immunodeficiency virus seropositivity. Each patient was categorized by the Walter Reed staging classification and serum concentrations of immunoglobulins were compared with patient staging. Serum IgM concentrations were normal in all but nine patients. Serum IgG concentrations were elevated in 74 of 107 patients, with no significant differences noted between different stages of disease severity. Serum IgA concentrations were elevated in 38 of 107 patients, with a significant relationship noted between increasing staging category and increasing serum IgA concentration (p = 0.0001). Serum IgA concentrations in patients with human immunodeficiency virus seropositivity may be a useful marker of immunologic progression of disease.

Original language	English
Pages (from-to)	965-970
Number of pages	6
Journal	The Journal of Allergy and Clinical Immunology
Volume	82
Issue number	6
DOIs	https://doi.org/10.1016/0091-6749(88)90132-7
State	Published - Dec 1988

Access to Document

10.1016/0091-6749(88)90132-7

Fingerprint Dive into the research topics of 'The relationship of serum IgA concentration to human immunodeficiency virus (HIV) infection: A cross-sectional study of HIV-seropositive individuals detected by screening in the United States Air Force'. Together they form a unique fingerprint.

Cite this

Fling, J. A., Fischer, J. R., Boswell, R. N., & Reid, M. J. (1988). The relationship of serum IgA concentration to human immunodeficiency virus (HIV) infection: A cross-sectional study of HIV-seropositive individuals detected by screening in the United States Air Force. The Journal of Allergy and Clinical Immunology, 82(6), 965-970. https://doi.org/10.1016/0091-6749(88)90132-7

@article{c33b5757090a48d98325b87c41ed3798,

title = "The relationship of serum IgA concentration to human immunodeficiency virus (HIV) infection: A cross-sectional study of HIV-seropositive individuals detected by screening in the United States Air Force",

abstract = "Serum immunoglobulins were measured in 107 patients with human immunodeficiency virus seropositivity. Each patient was categorized by the Walter Reed staging classification and serum concentrations of immunoglobulins were compared with patient staging. Serum IgM concentrations were normal in all but nine patients. Serum IgG concentrations were elevated in 74 of 107 patients, with no significant differences noted between different stages of disease severity. Serum IgA concentrations were elevated in 38 of 107 patients, with a significant relationship noted between increasing staging category and increasing serum IgA concentration (p = 0.0001). Serum IgA concentrations in patients with human immunodeficiency virus seropositivity may be a useful marker of immunologic progression of disease.",

author = "Fling, {John A.} and Fischer, {Joseph R.} and Boswell, {R. Neal} and Reid, {Michael J.}",

year = "1988",

month = dec,

doi = "10.1016/0091-6749(88)90132-7",

language = "English",

volume = "82",

pages = "965--970",

journal = "The Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

publisher = "Mosby Inc.",

number = "6",

}

Fling, JA, Fischer, JR, Boswell, RN & Reid, MJ 1988, 'The relationship of serum IgA concentration to human immunodeficiency virus (HIV) infection: A cross-sectional study of HIV-seropositive individuals detected by screening in the United States Air Force', The Journal of Allergy and Clinical Immunology, vol. 82, no. 6, pp. 965-970. https://doi.org/10.1016/0091-6749(88)90132-7

The relationship of serum IgA concentration to human immunodeficiency virus (HIV) infection : A cross-sectional study of HIV-seropositive individuals detected by screening in the United States Air Force. / Fling, John A.; Fischer, Joseph R.; Boswell, R. Neal; Reid, Michael J.

In: The Journal of Allergy and Clinical Immunology, Vol. 82, No. 6, 12.1988, p. 965-970.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The relationship of serum IgA concentration to human immunodeficiency virus (HIV) infection

T2 - A cross-sectional study of HIV-seropositive individuals detected by screening in the United States Air Force

AU - Fling, John A.

AU - Fischer, Joseph R.

AU - Boswell, R. Neal

AU - Reid, Michael J.

PY - 1988/12

Y1 - 1988/12

N2 - Serum immunoglobulins were measured in 107 patients with human immunodeficiency virus seropositivity. Each patient was categorized by the Walter Reed staging classification and serum concentrations of immunoglobulins were compared with patient staging. Serum IgM concentrations were normal in all but nine patients. Serum IgG concentrations were elevated in 74 of 107 patients, with no significant differences noted between different stages of disease severity. Serum IgA concentrations were elevated in 38 of 107 patients, with a significant relationship noted between increasing staging category and increasing serum IgA concentration (p = 0.0001). Serum IgA concentrations in patients with human immunodeficiency virus seropositivity may be a useful marker of immunologic progression of disease.

AB - Serum immunoglobulins were measured in 107 patients with human immunodeficiency virus seropositivity. Each patient was categorized by the Walter Reed staging classification and serum concentrations of immunoglobulins were compared with patient staging. Serum IgM concentrations were normal in all but nine patients. Serum IgG concentrations were elevated in 74 of 107 patients, with no significant differences noted between different stages of disease severity. Serum IgA concentrations were elevated in 38 of 107 patients, with a significant relationship noted between increasing staging category and increasing serum IgA concentration (p = 0.0001). Serum IgA concentrations in patients with human immunodeficiency virus seropositivity may be a useful marker of immunologic progression of disease.

UR - http://www.scopus.com/inward/record.url?scp=0024203748&partnerID=8YFLogxK

U2 - 10.1016/0091-6749(88)90132-7

DO - 10.1016/0091-6749(88)90132-7

M3 - Article

C2 - 3264560

AN - SCOPUS:0024203748

VL - 82

SP - 965

EP - 970

JO - The Journal of Allergy and Clinical Immunology

JF - The Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 6

ER -

The relationship of serum IgA concentration to human immunodeficiency virus (HIV) infection: A cross-sectional study of HIV-seropositive individuals detected by screening in the United States Air Force

Abstract

Access to Document

Other files and links

Cite this