The relationship of serum IgA concentration to human immunodeficiency virus (HIV) infection: A cross-sectional study of HIV-seropositive individuals detected by screening in the United States Air Force

John A. Fling; Joseph R. Fischer; R. Neal Boswell; Michael J. Reid

doi:10.1016/0091-6749(88)90132-7

The relationship of serum IgA concentration to human immunodeficiency virus (HIV) infection: A cross-sectional study of HIV-seropositive individuals detected by screening in the United States Air Force

John A. Fling, Joseph R. Fischer, R. Neal Boswell, Michael J. Reid

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Serum immunoglobulins were measured in 107 patients with human immunodeficiency virus seropositivity. Each patient was categorized by the Walter Reed staging classification and serum concentrations of immunoglobulins were compared with patient staging. Serum IgM concentrations were normal in all but nine patients. Serum IgG concentrations were elevated in 74 of 107 patients, with no significant differences noted between different stages of disease severity. Serum IgA concentrations were elevated in 38 of 107 patients, with a significant relationship noted between increasing staging category and increasing serum IgA concentration (p = 0.0001). Serum IgA concentrations in patients with human immunodeficiency virus seropositivity may be a useful marker of immunologic progression of disease.

Original language	English
Pages (from-to)	965-970
Number of pages	6
Journal	The Journal of Allergy and Clinical Immunology
Volume	82
Issue number	6
DOIs	https://doi.org/10.1016/0091-6749(88)90132-7
State	Published - Dec 1988

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Fling, J. A., Fischer, J. R., Boswell, R. N., & Reid, M. J. (1988). The relationship of serum IgA concentration to human immunodeficiency virus (HIV) infection: A cross-sectional study of HIV-seropositive individuals detected by screening in the United States Air Force. The Journal of Allergy and Clinical Immunology, 82(6), 965-970. https://doi.org/10.1016/0091-6749(88)90132-7

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abstract = "Serum immunoglobulins were measured in 107 patients with human immunodeficiency virus seropositivity. Each patient was categorized by the Walter Reed staging classification and serum concentrations of immunoglobulins were compared with patient staging. Serum IgM concentrations were normal in all but nine patients. Serum IgG concentrations were elevated in 74 of 107 patients, with no significant differences noted between different stages of disease severity. Serum IgA concentrations were elevated in 38 of 107 patients, with a significant relationship noted between increasing staging category and increasing serum IgA concentration (p = 0.0001). Serum IgA concentrations in patients with human immunodeficiency virus seropositivity may be a useful marker of immunologic progression of disease.",

author = "Fling, {John A.} and Fischer, {Joseph R.} and Boswell, {R. Neal} and Reid, {Michael J.}",

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Fling, JA, Fischer, JR, Boswell, RN & Reid, MJ 1988, 'The relationship of serum IgA concentration to human immunodeficiency virus (HIV) infection: A cross-sectional study of HIV-seropositive individuals detected by screening in the United States Air Force', The Journal of Allergy and Clinical Immunology, vol. 82, no. 6, pp. 965-970. https://doi.org/10.1016/0091-6749(88)90132-7

The relationship of serum IgA concentration to human immunodeficiency virus (HIV) infection : A cross-sectional study of HIV-seropositive individuals detected by screening in the United States Air Force. / Fling, John A.; Fischer, Joseph R.; Boswell, R. Neal; Reid, Michael J.

In: The Journal of Allergy and Clinical Immunology, Vol. 82, No. 6, 12.1988, p. 965-970.

Research output: Contribution to journal › Article › peer-review

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AB - Serum immunoglobulins were measured in 107 patients with human immunodeficiency virus seropositivity. Each patient was categorized by the Walter Reed staging classification and serum concentrations of immunoglobulins were compared with patient staging. Serum IgM concentrations were normal in all but nine patients. Serum IgG concentrations were elevated in 74 of 107 patients, with no significant differences noted between different stages of disease severity. Serum IgA concentrations were elevated in 38 of 107 patients, with a significant relationship noted between increasing staging category and increasing serum IgA concentration (p = 0.0001). Serum IgA concentrations in patients with human immunodeficiency virus seropositivity may be a useful marker of immunologic progression of disease.

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