Abstract
Serum immunoglobulins were measured in 107 patients with human immunodeficiency virus seropositivity. Each patient was categorized by the Walter Reed staging classification and serum concentrations of immunoglobulins were compared with patient staging. Serum IgM concentrations were normal in all but nine patients. Serum IgG concentrations were elevated in 74 of 107 patients, with no significant differences noted between different stages of disease severity. Serum IgA concentrations were elevated in 38 of 107 patients, with a significant relationship noted between increasing staging category and increasing serum IgA concentration (p = 0.0001). Serum IgA concentrations in patients with human immunodeficiency virus seropositivity may be a useful marker of immunologic progression of disease.
| Original language | English |
|---|---|
| Pages (from-to) | 965-970 |
| Number of pages | 6 |
| Journal | The Journal of Allergy and Clinical Immunology |
| Volume | 82 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1988 |
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The relationship of serum IgA concentration to human immunodeficiency virus (HIV) infection : A cross-sectional study of HIV-seropositive individuals detected by screening in the United States Air Force. / Fling, John A.; Fischer, Joseph R.; Boswell, R. Neal; Reid, Michael J.
In: The Journal of Allergy and Clinical Immunology, Vol. 82, No. 6, 12.1988, p. 965-970.Research output: Contribution to journal › Article
TY - JOUR
T1 - The relationship of serum IgA concentration to human immunodeficiency virus (HIV) infection
T2 - A cross-sectional study of HIV-seropositive individuals detected by screening in the United States Air Force
AU - Fling, John A.
AU - Fischer, Joseph R.
AU - Boswell, R. Neal
AU - Reid, Michael J.
PY - 1988/12
Y1 - 1988/12
N2 - Serum immunoglobulins were measured in 107 patients with human immunodeficiency virus seropositivity. Each patient was categorized by the Walter Reed staging classification and serum concentrations of immunoglobulins were compared with patient staging. Serum IgM concentrations were normal in all but nine patients. Serum IgG concentrations were elevated in 74 of 107 patients, with no significant differences noted between different stages of disease severity. Serum IgA concentrations were elevated in 38 of 107 patients, with a significant relationship noted between increasing staging category and increasing serum IgA concentration (p = 0.0001). Serum IgA concentrations in patients with human immunodeficiency virus seropositivity may be a useful marker of immunologic progression of disease.
AB - Serum immunoglobulins were measured in 107 patients with human immunodeficiency virus seropositivity. Each patient was categorized by the Walter Reed staging classification and serum concentrations of immunoglobulins were compared with patient staging. Serum IgM concentrations were normal in all but nine patients. Serum IgG concentrations were elevated in 74 of 107 patients, with no significant differences noted between different stages of disease severity. Serum IgA concentrations were elevated in 38 of 107 patients, with a significant relationship noted between increasing staging category and increasing serum IgA concentration (p = 0.0001). Serum IgA concentrations in patients with human immunodeficiency virus seropositivity may be a useful marker of immunologic progression of disease.
UR - http://www.scopus.com/inward/record.url?scp=0024203748&partnerID=8YFLogxK
U2 - 10.1016/0091-6749(88)90132-7
DO - 10.1016/0091-6749(88)90132-7
M3 - Article
C2 - 3264560
AN - SCOPUS:0024203748
VL - 82
SP - 965
EP - 970
JO - The Journal of Allergy and Clinical Immunology
JF - The Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 6
ER -