The ratio of human X chromosome to autosome diversity is positively correlated with genetic distance from genes

Michael F. Hammer; August E. Woerner; Fernando L. Mendez; Joseph C. Watkins; Murray P. Cox; Jeffrey D. Wall

doi:10.1038/ng.651

The ratio of human X chromosome to autosome diversity is positively correlated with genetic distance from genes

Michael F. Hammer, August E. Woerner, Fernando L. Mendez, Joseph C. Watkins, Murray P. Cox, Jeffrey D. Wall

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Abstract

The ratio of X-linked to autosomal diversity was estimated from an analysis of six human genome sequences and found to deviate from the expected value of 0.75. However, the direction of this deviation depends on whether a particular sequence is close to or far from the nearest gene. This pattern may be explained by stronger locally acting selection on X-linked genes compared with autosomal genes, combined with larger effective population sizes for females than for males.

Original language	English
Pages (from-to)	830-831
Number of pages	2
Journal	Nature Genetics
Volume	42
Issue number	10
DOIs	https://doi.org/10.1038/ng.651
State	Published - Oct 2010

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abstract = "The ratio of X-linked to autosomal diversity was estimated from an analysis of six human genome sequences and found to deviate from the expected value of 0.75. However, the direction of this deviation depends on whether a particular sequence is close to or far from the nearest gene. This pattern may be explained by stronger locally acting selection on X-linked genes compared with autosomal genes, combined with larger effective population sizes for females than for males.",

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AU - Wall, Jeffrey D.

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The ratio of human X chromosome to autosome diversity is positively correlated with genetic distance from genes

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