The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

Keyphrases

• Estrogen 100%
• 17-estradiol 100%
• Prodrug 100%
• Estrogen-responsive 100%
• Dien 100%
• Neuroprotection 60%
• Hormone Therapy 40%
• Surgical Menopause 40%
• Estrogen Deficiency 40%
• Treatment Regimen 20%
• Route of Administration 20%
• Human Brain 20%
• Adverse Effects 20%
• Tumor Growth 20%
• Rodents 20%
• Deprivation 20%
• Small Molecules 20%
• Administration Regimen 20%
• Rat Stroke Model 20%
• Uterus 20%
• Functional Data 20%
• Mechanistic Data 20%
• Peripheral Response 20%
• Systemic Administration 20%
• Estradiol Treatment 20%
• Bioprecursor Prodrug 20%
• Neurological Symptoms 20%
• Rapid Formation 20%
• Changes in Gene Expression 20%
• In Vivo Imaging 20%
• Maladies 20%
• Menopause 20%
• Bioanalytical Assay 20%
• Neuronal Morphology 20%
• Prodrug Approach 20%
• Brain-derived Estrogen 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Diethylstilbestrol 100%
• Prodrug 100%
• Estrogen 100%
• Neuroprotection 42%
• Endocrine Therapy 28%
• Estrogen Deficiency 28%
• Side Effect 28%
• Tumor Growth 14%
• Route of Administration 14%
• Systemic Administration 14%
• Boron 10 14%
• Cerebrovascular Accident 14%
• Rat 14%

Neuroscience

• Diethylstilbestrol 100%
• Prodrug 100%
• Estrogen 100%
• Neuroprotection 33%
• In Vivo 22%
• Hormone Therapy 22%
• Side Effect 22%
• Gene Expression 11%
• Cerebrovascular Accident 11%
• Human Brain 11%
• Psychopathology 11%