TY - JOUR
T1 - The potential therapeutic benefits of low frequency haemodynamic oscillations
AU - Anderson, Garen K.
AU - Rickards, Caroline A.
N1 - Funding Information:
G.K.A. was funded by a National Institutes of Health (NIH)‐supported Neurobiology of Aging Training Grant (T32 AG020494, Principal Investigator: N. Sumien), and an American Heart Association Predoctoral Fellowship (20PRE35210249). C.A.R. was funded by an American Heart Association Grant‐in‐Aid (17GRNT33671110) and an American Heart Association Transformational Project Award (19TPA34910073).
Publisher Copyright:
© 2022 The Authors. The Journal of Physiology © 2022 The Physiological Society.
PY - 2022/9/1
Y1 - 2022/9/1
N2 - Haemodynamic oscillations occurring at frequencies below the rate of respiration have been observed experimentally for more than a century. Much of the research regarding these oscillations, observed in arterial pressure and blood flow, has focused on mechanisms of generation and methods of quantification. However, examination of the physiological role of these oscillations has been limited. Multiple studies have demonstrated that oscillations in arterial pressure and blood flow are associated with the protection in tissue oxygenation or functional capillary density during conditions of reduced tissue perfusion. There is also evidence that oscillatory blood flow can improve clearance of interstitial fluid, with a growing number of studies demonstrating a role for oscillatory blood flow to aid in clearance of debris from the brain. The therapeutic potential of these haemodynamic oscillations is an important new area of research which may have beneficial impact in treating conditions such as stroke, cardiac arrest, blood loss injuries, sepsis, or even Alzheimer's disease and vascular dementia. (Figure presented.).
AB - Haemodynamic oscillations occurring at frequencies below the rate of respiration have been observed experimentally for more than a century. Much of the research regarding these oscillations, observed in arterial pressure and blood flow, has focused on mechanisms of generation and methods of quantification. However, examination of the physiological role of these oscillations has been limited. Multiple studies have demonstrated that oscillations in arterial pressure and blood flow are associated with the protection in tissue oxygenation or functional capillary density during conditions of reduced tissue perfusion. There is also evidence that oscillatory blood flow can improve clearance of interstitial fluid, with a growing number of studies demonstrating a role for oscillatory blood flow to aid in clearance of debris from the brain. The therapeutic potential of these haemodynamic oscillations is an important new area of research which may have beneficial impact in treating conditions such as stroke, cardiac arrest, blood loss injuries, sepsis, or even Alzheimer's disease and vascular dementia. (Figure presented.).
KW - haemodynamic oscillations
KW - haemodynamic variability
KW - tissue oxygenation
UR - http://www.scopus.com/inward/record.url?scp=85137003390&partnerID=8YFLogxK
U2 - 10.1113/JP282605
DO - 10.1113/JP282605
M3 - Article
C2 - 35883272
AN - SCOPUS:85137003390
SN - 0022-3751
VL - 600
SP - 3905
EP - 3919
JO - Journal of Physiology
JF - Journal of Physiology
IS - 17
ER -