The postantifungal and paradoxical effects of echinocandins against Candida spp.

Brad Moriyama, Stacey A. Henning, Scott Robert Penzak, Thomas J. Walsh

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Evaluation of: Shields RK, Nguyen MH, Press EG, Clancy CJ. Five-minute exposure to caspofungin results in prolonged postantifungal effects and eliminates the paradoxical growth of Candida albicans. Antimicrob. Agents Chemother. 55(7), 3598-3602 (2011). Echinocandins induce a postantifungal effect and a paradoxical effect. The postantifungal effect is a concentration- dependent process that allows for sustained kill of Candida spp. after relatively brief exposures to a compound. The paradoxical effect is growth that occurs at high echinocandin concentrations above the MIC. Paradoxical growth varies in terms of media, species, strain and type of echinocandin. The study by Shields et al. evaluated the impact of a brief exposure of caspofungin on paradoxical growth and postantifungal effects in Candida albicans isolates. In the postantifungal effect experiments, prolonged concentration-dependent killing occurred. Maximum postantifungal effects occurred with caspofungin exposures of 5 or 15 min. A brief exposure of caspofungin eliminated the paradoxical growth that was observed in the time-kill experiments. The report by Shields et al. illustrates that short exposures to an echinocandin may lead to prolonged postantifungal effects and furthers our understanding of the paradoxical effect in C. albicans.

Original languageEnglish
Pages (from-to)565-569
Number of pages5
JournalFuture Microbiology
Volume7
Issue number5
DOIs
StatePublished - 1 May 2012

Keywords

  • Candida spp
  • echinocandin
  • paradoxical effect
  • postantifungal effect

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