@article{116b69c3bd8c4b638d79df3eb57380e1,
title = "The peopling of South America and the trans-Andean gene flow of the first settlers",
abstract = "Genetic and archaeological data indicate that the initial Paleoindian settlers of South America followed two entry routes separated by the Andes and the Amazon rainforest. The interactions between these paths and their impact on the peopling of South America remain unclear. Analysis of genetic variation in the Peruvian Andes and regions located south of the Amazon River might provide clues on this issue. We analyzed mitochondrial DNA variation at different Andean locations and >360,000 autosomal SNPs from 28 Native American ethnic groups to evaluate different trans-Andean demographic scenarios. Our data reveal that the Peruvian Altiplano was an important enclave for early Paleoindian expansions and point to a genetic continuity in the Andes until recent times, which was only marginally affected by gene flow from the Amazonian lowlands. Genomic variation shows a good fit with the archaeological evidence, indicating that the genetic interactions between the descendants of the settlers that followed the Pacific and Atlantic routes were extremely limited.",
author = "Alberto G{\'o}mez-Carballa and Jacobo Pardo-Seco and Stefania Brandini and Alessandro Achilli and Perego, {Ugo A.} and Coble, {Michael D.} and Diegoli, {Toni M.} and Vanesa Alvarez-Iglesias and Federico Martin{\'o}n-Torres and Anna Olivieri and Antonio Torroni and Antonio Salas",
note = "Funding Information: We thank Juan Carlos Jaime for help, support, and access to samples. This study received support from the Instituto de Salud Carlos III (Proyecto de Investigaci{\'o}n en Salud, Acci{\'o}n Estrat{\'e}gica en Salud): project GePEM ISCIII/PI16/01478/Cofinanciado FEDER) (to A.S.); project ReSVinext ISCIII/PI16/01569/Cofinanciado FEDER (to F.M.-T.); Conseller{\'i}a de Sanidade, Xunta de Galicia (RHI07/2-intensificaci{\'o}n actividad investigadora, PS09749 and 10PXIB918184PR), Instituto de Salud Carlos III (Intensificaci{\'o}n de la actividad investigadora 2007–2012, PI16/01569) (to F.M.-T.); Fondo de Investigaci{\'o}n Sanitaria (FIS; PI070069/PI1000540) del plan nacional de I + D + I and {\textquoteleft}fondos FEDER{\textquoteright} (to F.M.-T.); 2016-PG071 Consolidaci{\'o}n e Estructuraci{\'o}n REDES 2016GI-1344 G3VIP (Grupo Gallego de Gen{\'e}tica Vacunas Infecciones y Pediatr{\'i}a, ED341D R2016/021) (to A.S. and F.M.-T.); the University of Pavia strategic theme “Towards a governance model for international migration: an interdisciplinary and diachronic perspective” (MIGRAT-IN-G) (to A.A., A.O., and A.T.); the Italian Ministry of Education, University and Research: Progetti Futuro in Ricerca 2012 (RBFR126B8I) (to A.A. and A.O.); the Progetti Ricerca Interesse Nazionale 2012 (to A.A. and A.T.); Dipartimenti di Eccellenza Program (2018–2022)—Dept. of Biology and Biotechnology “L. Spallanzani,” University of Pavia (to A.A., A.O., and A.T.); and the ERC Consolidator Grant: CoG-2014, No. 648535 (to A.A.). Publisher Copyright: {\textcopyright} 2018 G{\'o}mez-Carballa et al.",
year = "2018",
month = jun,
doi = "10.1101/gr.234674.118",
language = "English",
volume = "28",
pages = "767--779",
journal = "Genome Research",
issn = "1088-9051",
publisher = "Cold Spring Harbor Laboratory Press",
number = "6",
}