The pathophysiology of neurofibromatosis: IX. Paternal age as a factor in the origin of new mutations

V. M. Riccardi, C. E. Dobson, Ranajit Chakraborty, C. Bontke

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Von Recklinghausen neurofibromatosis is characterized by a relatively large proportion of apparently nonfamilial cases, presumed spontaneous mutations. This paper analyzes the distribution of paternal and maternal ages for 187 patients with von Recklinghausen disease representing the first definite case in their respective families. Mean paternal age was 32.8 years and mean maternal age was 27.4 years, both being significantly greater than for control populations (P equal to or less than .001). The advanced paternal age was not accounted for by the increase in maternal age. The methodology of controlling the general population paternal ages for each patient's birth year is described.

Original languageEnglish
Pages (from-to)169-176
Number of pages8
JournalAmerican Journal of Medical Genetics
Volume18
Issue number1
DOIs
StatePublished - 1 Jan 1984

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Paternal Age
Neurofibromatoses
Maternal Age
Mutation
Neurofibromatosis 1
Population
Parturition

Cite this

Riccardi, V. M. ; Dobson, C. E. ; Chakraborty, Ranajit ; Bontke, C. / The pathophysiology of neurofibromatosis : IX. Paternal age as a factor in the origin of new mutations. In: American Journal of Medical Genetics. 1984 ; Vol. 18, No. 1. pp. 169-176.
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The pathophysiology of neurofibromatosis : IX. Paternal age as a factor in the origin of new mutations. / Riccardi, V. M.; Dobson, C. E.; Chakraborty, Ranajit; Bontke, C.

In: American Journal of Medical Genetics, Vol. 18, No. 1, 01.01.1984, p. 169-176.

Research output: Contribution to journalArticle

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