The Panama aging research initiative longitudinal study

Panama Aging Research Initiative Group

Research output: Contribution to journalArticle

Abstract

The Panama Aging Research Initiative is a cohort study of 423 adults aged ≥65 years recruited from an outpatient geriatric department of Panama’s largest public hospital, the Social Security Fund’s Dr Arnulfo Arias Madrid Hospital Complex (Complejo Hospitalario Dr Arnulfo Arias Madrid de la Caja de Seguro Social). The study provides the first reports of modifiable and non-modifiable risk factors of cognitive impairment and dementia, as well as various health conditions common among older adults in Panama, including chronic illnesses, polypharmacy and rates of comorbidity. The initial study, conducted September 2012–May 2016, included a clinical interview; physical assessments of body mass index and handgrip strength; and cognitive testing, plus non-fasting blood draws for measurements of genetic (Apolipoprotein E genotype) and blood-based biological markers. Information was collected regarding limitations in activities of daily living, symptoms of depression and fall incidents. A subsample of participants provided cerebrospinal fluid to measure proteins related to Alzheimer’s disease; another subsample underwent ultrasonography and electroencephalography. This report describes the general study design and highlights lessons learned and future directions. In particular, drawing on lessons learned from this clinical research, a community-based prospective cohort study is currently under way among older adults in Panama to validate a blood-based biomarker profile for detecting mild cognitive impairment and Alzheimer’s disease, as well as risk factors for cognitive decline.

Original languageEnglish
Pages (from-to)54-58
Number of pages5
JournalMEDICC Review
Volume21
Issue number2-3
StatePublished - 1 Jan 2019

Fingerprint

Panama
Longitudinal Studies
Alzheimer Disease
Cohort Studies
Biomarkers
Research
Polypharmacy
Social Security
Public Hospitals
Apolipoproteins E
Financial Management
Activities of Daily Living
Geriatrics
Cerebrospinal Fluid
Dementia
Comorbidity
Electroencephalography
Ultrasonography
Body Mass Index
Chronic Disease

Keywords

  • Aging
  • Biomarkers
  • Chronic disease
  • Cognition
  • Dementia
  • Latin America
  • Panama

Cite this

Panama Aging Research Initiative Group (2019). The Panama aging research initiative longitudinal study. MEDICC Review, 21(2-3), 54-58.
Panama Aging Research Initiative Group. / The Panama aging research initiative longitudinal study. In: MEDICC Review. 2019 ; Vol. 21, No. 2-3. pp. 54-58.
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author = "{Panama Aging Research Initiative Group} and Villarreal, {Alcibiades E.} and P{\'e}rez-Lao, {Ambar R.} and Oviedo, {Diana C.} and Shantal Grajales and Carreira, {Maria B.} and Britton, {Gabrielle B.} and Alejandro Vernaza and Aquiles Aguilar and Aron Benzadon and Astevia Montalv{\'a}n and Baltazar Isaza and David Dondis and Elena Blake and Frank Ferro and Gabriela Carrillo-Pujol and Ivonne Torres-Atencio and Cede{\~n}o, {Jos{\'e} A.} and Josefina Fletcher and Josu{\'e} Morales and Juan Moscoso and Lavinia Wesley and G{\'o}mez, {Lee Anne} and Lineth L{\'o}pez and Luis Lee and Luis Ortiz and Luis Sotillo and Mar{\'i}a Mendieta and Nelson Novarro and Patricia Gonz{\'a}lez and Rainier Rodr{\'i}guez and Ram{\'o}n Zarak and Ribana Molino and O’Bryant, {Sid E.} and Vanesa Gonz{\'a}lez and Vanessa Castillo and Viterbo Osorio and Vivian V{\'a}squez and Yina Gutierrez",
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Panama Aging Research Initiative Group 2019, 'The Panama aging research initiative longitudinal study', MEDICC Review, vol. 21, no. 2-3, pp. 54-58.

The Panama aging research initiative longitudinal study. / Panama Aging Research Initiative Group.

In: MEDICC Review, Vol. 21, No. 2-3, 01.01.2019, p. 54-58.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Panama Aging Research Initiative Group

AU - Villarreal, Alcibiades E.

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AU - Oviedo, Diana C.

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AU - Carreira, Maria B.

AU - Britton, Gabrielle B.

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AU - Benzadon, Aron

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AU - Isaza, Baltazar

AU - Dondis, David

AU - Blake, Elena

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AU - Carrillo-Pujol, Gabriela

AU - Torres-Atencio, Ivonne

AU - Cedeño, José A.

AU - Fletcher, Josefina

AU - Morales, Josué

AU - Moscoso, Juan

AU - Wesley, Lavinia

AU - Gómez, Lee Anne

AU - López, Lineth

AU - Lee, Luis

AU - Ortiz, Luis

AU - Sotillo, Luis

AU - Mendieta, María

AU - Novarro, Nelson

AU - González, Patricia

AU - Rodríguez, Rainier

AU - Zarak, Ramón

AU - Molino, Ribana

AU - O’Bryant, Sid E.

AU - González, Vanesa

AU - Castillo, Vanessa

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AU - Vásquez, Vivian

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Panama Aging Research Initiative Group. The Panama aging research initiative longitudinal study. MEDICC Review. 2019 Jan 1;21(2-3):54-58.