Abstract
The Panama Aging Research Initiative is a cohort study of 423 adults aged ≥65 years recruited from an outpatient geriatric department of Panama’s largest public hospital, the Social Security Fund’s Dr Arnulfo Arias Madrid Hospital Complex (Complejo Hospitalario Dr Arnulfo Arias Madrid de la Caja de Seguro Social). The study provides the first reports of modifiable and non-modifiable risk factors of cognitive impairment and dementia, as well as various health conditions common among older adults in Panama, including chronic illnesses, polypharmacy and rates of comorbidity. The initial study, conducted September 2012–May 2016, included a clinical interview; physical assessments of body mass index and handgrip strength; and cognitive testing, plus non-fasting blood draws for measurements of genetic (Apolipoprotein E genotype) and blood-based biological markers. Information was collected regarding limitations in activities of daily living, symptoms of depression and fall incidents. A subsample of participants provided cerebrospinal fluid to measure proteins related to Alzheimer’s disease; another subsample underwent ultrasonography and electroencephalography. This report describes the general study design and highlights lessons learned and future directions. In particular, drawing on lessons learned from this clinical research, a community-based prospective cohort study is currently under way among older adults in Panama to validate a blood-based biomarker profile for detecting mild cognitive impairment and Alzheimer’s disease, as well as risk factors for cognitive decline.
| Original language | English |
|---|---|
| Pages (from-to) | 54-58 |
| Number of pages | 5 |
| Journal | MEDICC Review |
| Volume | 21 |
| Issue number | 2-3 |
| State | Published - 1 Jan 2019 |
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Keywords
- Aging
- Biomarkers
- Chronic disease
- Cognition
- Dementia
- Latin America
- Panama
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The Panama aging research initiative longitudinal study. / Panama Aging Research Initiative Group.
In: MEDICC Review, Vol. 21, No. 2-3, 01.01.2019, p. 54-58.Research output: Contribution to journal › Article
TY - JOUR
T1 - The Panama aging research initiative longitudinal study
AU - Panama Aging Research Initiative Group
AU - Villarreal, Alcibiades E.
AU - Pérez-Lao, Ambar R.
AU - Oviedo, Diana C.
AU - Grajales, Shantal
AU - Carreira, Maria B.
AU - Britton, Gabrielle B.
AU - Vernaza, Alejandro
AU - Aguilar, Aquiles
AU - Benzadon, Aron
AU - Montalván, Astevia
AU - Isaza, Baltazar
AU - Dondis, David
AU - Blake, Elena
AU - Ferro, Frank
AU - Carrillo-Pujol, Gabriela
AU - Torres-Atencio, Ivonne
AU - Cedeño, José A.
AU - Fletcher, Josefina
AU - Morales, Josué
AU - Moscoso, Juan
AU - Wesley, Lavinia
AU - Gómez, Lee Anne
AU - López, Lineth
AU - Lee, Luis
AU - Ortiz, Luis
AU - Sotillo, Luis
AU - Mendieta, María
AU - Novarro, Nelson
AU - González, Patricia
AU - Rodríguez, Rainier
AU - Zarak, Ramón
AU - Molino, Ribana
AU - O’Bryant, Sid E.
AU - González, Vanesa
AU - Castillo, Vanessa
AU - Osorio, Viterbo
AU - Vásquez, Vivian
AU - Gutierrez, Yina
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The Panama Aging Research Initiative is a cohort study of 423 adults aged ≥65 years recruited from an outpatient geriatric department of Panama’s largest public hospital, the Social Security Fund’s Dr Arnulfo Arias Madrid Hospital Complex (Complejo Hospitalario Dr Arnulfo Arias Madrid de la Caja de Seguro Social). The study provides the first reports of modifiable and non-modifiable risk factors of cognitive impairment and dementia, as well as various health conditions common among older adults in Panama, including chronic illnesses, polypharmacy and rates of comorbidity. The initial study, conducted September 2012–May 2016, included a clinical interview; physical assessments of body mass index and handgrip strength; and cognitive testing, plus non-fasting blood draws for measurements of genetic (Apolipoprotein E genotype) and blood-based biological markers. Information was collected regarding limitations in activities of daily living, symptoms of depression and fall incidents. A subsample of participants provided cerebrospinal fluid to measure proteins related to Alzheimer’s disease; another subsample underwent ultrasonography and electroencephalography. This report describes the general study design and highlights lessons learned and future directions. In particular, drawing on lessons learned from this clinical research, a community-based prospective cohort study is currently under way among older adults in Panama to validate a blood-based biomarker profile for detecting mild cognitive impairment and Alzheimer’s disease, as well as risk factors for cognitive decline.
AB - The Panama Aging Research Initiative is a cohort study of 423 adults aged ≥65 years recruited from an outpatient geriatric department of Panama’s largest public hospital, the Social Security Fund’s Dr Arnulfo Arias Madrid Hospital Complex (Complejo Hospitalario Dr Arnulfo Arias Madrid de la Caja de Seguro Social). The study provides the first reports of modifiable and non-modifiable risk factors of cognitive impairment and dementia, as well as various health conditions common among older adults in Panama, including chronic illnesses, polypharmacy and rates of comorbidity. The initial study, conducted September 2012–May 2016, included a clinical interview; physical assessments of body mass index and handgrip strength; and cognitive testing, plus non-fasting blood draws for measurements of genetic (Apolipoprotein E genotype) and blood-based biological markers. Information was collected regarding limitations in activities of daily living, symptoms of depression and fall incidents. A subsample of participants provided cerebrospinal fluid to measure proteins related to Alzheimer’s disease; another subsample underwent ultrasonography and electroencephalography. This report describes the general study design and highlights lessons learned and future directions. In particular, drawing on lessons learned from this clinical research, a community-based prospective cohort study is currently under way among older adults in Panama to validate a blood-based biomarker profile for detecting mild cognitive impairment and Alzheimer’s disease, as well as risk factors for cognitive decline.
KW - Aging
KW - Biomarkers
KW - Chronic disease
KW - Cognition
KW - Dementia
KW - Latin America
KW - Panama
UR - http://www.scopus.com/inward/record.url?scp=85070966635&partnerID=8YFLogxK
M3 - Article
C2 - 31373585
AN - SCOPUS:85070966635
VL - 21
SP - 54
EP - 58
JO - MEDICC Review
JF - MEDICC Review
SN - 1555-7960
IS - 2-3
ER -