The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H₂O₂-induced cell injury via NF-E2-related factor 2 (Nrf2) activation

Keyphrases

• Hydrogen Peroxide 100%
• Cell Injury 100%
• Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 100%
• Triterpenoids 100%
• RTA-408 100%
• Retinal pigment Epithelial Cells 100%
• Oxidative Stress 45%
• Apoptosis 18%
• Downstream Genes 18%
• Stress-induced 18%
• Grx1 18%
• Thioredoxin 1 (Trx1) 18%
• NAD(P)H:Quinone Oxidoreductase 1 (NQO1) 18%
• Knockdown 9%
• Small Interfering RNA (siRNA) 9%
• Protective Effect 9%
• Western Blot 9%
• Catalase 9%
• Age-related Macular Degeneration 9%
• Cell Viability 9%
• Natural Triterpenoids 9%
• Downstream Effects 9%
• Viability Loss 9%
• Hoechst 33342 9%
• Reduced GSH 9%
• ROS Production 9%
• Triterpenic Compounds 9%
• Fluorescent Staining 9%
• Heme oxygenase-1 (HO-1) 9%
• Annexin V/propidium Iodide 9%
• Phase II Enzymes 9%
• Epithelial Cell Damage 9%
• Stress Damage 9%
• Oxidized Glutathione 9%
• WST-8 Assay 9%
• Superoxide Dismutase 2 (SOD2) 9%
• Double Staining 9%
• Enzyme Activity 9%
• Colorimetric Assay 9%
• Downstream Target Genes 9%

Neuroscience

• Transcription Factor Nrf2 100%
• Hydrogen Peroxide 100%
• Epithelial Cells 100%
• Visual Pigment 100%
• Triterpenoid 100%
• Cell Damage 100%
• Oxidative Stress 71%
• Programmed Cell Death 28%
• Small Interfering RNA 14%
• Catalase 14%
• Western Blot 14%
• Age-Related Macular Degeneration 14%
• Staining Technique 14%
• Cell Viability 14%
• Enzyme Activity 14%
• Fluorescent Dye 14%
• Glutathione Disulfide 14%
• Propidium Iodide 14%
• Lipocortin 5 14%
• Hoechst 33342 14%
• Enzymes 14%

Immunology and Microbiology

• Cell Damage 100%
• Hydrogen Peroxide 100%
• Transcription Factor Nrf2 100%
• Oxidative Stress 71%
• Programmed Cell Death 28%
• Pretreatment 28%
• Western Blot 14%
• Staining 14%
• Enzyme Activity 14%
• Cell Viability 14%
• Fluorescence Labeling 14%
• Propidium Iodide 14%
• Glutathione 14%
• Catalase 14%