The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H₂O₂-induced cell injury via NF-E2-related factor 2 (Nrf2) activation

Medicine & Life Sciences

• N-(11-cyano-2,2,6a,6b,9,9,12a-heptmethyl-10,14-dioxo-1,3,4,5,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydro-2H-picen-4a-yl)-2-2-difluoropropionamide 100%
• NF-E2-Related Factor 2 65%
• Triterpenes 57%
• Retinal Pigments 56%
• Epithelial Cells 32%
• Wounds and Injuries 22%
• Glutathione Disulfide 16%
• Oxidative Stress 16%
• 2-(2-methoxy-4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H tetrazolium monosodium salt 7%
• bisbenzimide ethoxide trihydrochloride 6%
• Staining and Labeling 5%
• Apoptosis 5%
• Genes 5%
• Propidium 5%
• Annexin A5 5%
• Enzymes 5%
• Macular Degeneration 4%
• Catalase 4%
• Glutathione 4%
• Small Interfering RNA 3%
• Cell Survival 3%
• Western Blotting 3%

Chemical Compounds

• Retinal Pigment 62%
• Triterpenoid 54%
• Oxidative Stress 18%
• Cytoprotective 12%
• Propidium Iodide 12%
• Silencing RNA 11%
• Cell Viability 9%
• Glutathione 8%
• Protective 7%
• Enzyme Activity 7%