The multifunctional protein Kinase C-ε in cancer development and progression

Kirti Jain, Alakananda Basu

Research output: Contribution to journalReview articleResearchpeer-review

24 Citations (Scopus)

Abstract

The protein kinase C (PKC) family proteins are important signal transducers and have long been the focus of cancer research. PKCε, a member of this family, is overexpressed in most solid tumors and plays critical roles in different processes that lead to cancer development. Studies using cell lines and animal models demonstrated the transforming potential of PKCε. While earlier research established the survival functions of PKCε, recent studies revealed its role in cell migration, invasion and cancer metastasis. PKCε has also been implicated in epithelial to mesenchymal transition (EMT), which may be the underlying mechanism by which it contributes to cell motility. In addition, PKCε affects cell-extracellular matrix (ECM) interactions by direct regulation of the cytoskeletal elements. Recent studies have also linked PKCε signaling to cancer stem cell functioning. This review focuses on the role of PKCε in different processes that lead to cancer development and progression. We also discussed current literatures on the pursuit of PKCε as a target for cancer therapy.

Original languageEnglish
Pages (from-to)860-878
Number of pages19
JournalCancers
Volume6
Issue number2
DOIs
StatePublished - 1 Jan 2014

Fingerprint

Protein Kinase C
Neoplasms
Cell Movement
Epithelial-Mesenchymal Transition
Neoplastic Stem Cells
Transducers
Research
Extracellular Matrix
Animal Models
Neoplasm Metastasis
Cell Line

Keywords

  • Cancer stem cells
  • EMT
  • Metastasis
  • MicroRNA
  • PKCε
  • Survival

Cite this

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title = "The multifunctional protein Kinase C-ε in cancer development and progression",
abstract = "The protein kinase C (PKC) family proteins are important signal transducers and have long been the focus of cancer research. PKCε, a member of this family, is overexpressed in most solid tumors and plays critical roles in different processes that lead to cancer development. Studies using cell lines and animal models demonstrated the transforming potential of PKCε. While earlier research established the survival functions of PKCε, recent studies revealed its role in cell migration, invasion and cancer metastasis. PKCε has also been implicated in epithelial to mesenchymal transition (EMT), which may be the underlying mechanism by which it contributes to cell motility. In addition, PKCε affects cell-extracellular matrix (ECM) interactions by direct regulation of the cytoskeletal elements. Recent studies have also linked PKCε signaling to cancer stem cell functioning. This review focuses on the role of PKCε in different processes that lead to cancer development and progression. We also discussed current literatures on the pursuit of PKCε as a target for cancer therapy.",
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The multifunctional protein Kinase C-ε in cancer development and progression. / Jain, Kirti; Basu, Alakananda.

In: Cancers, Vol. 6, No. 2, 01.01.2014, p. 860-878.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - The multifunctional protein Kinase C-ε in cancer development and progression

AU - Jain, Kirti

AU - Basu, Alakananda

PY - 2014/1/1

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N2 - The protein kinase C (PKC) family proteins are important signal transducers and have long been the focus of cancer research. PKCε, a member of this family, is overexpressed in most solid tumors and plays critical roles in different processes that lead to cancer development. Studies using cell lines and animal models demonstrated the transforming potential of PKCε. While earlier research established the survival functions of PKCε, recent studies revealed its role in cell migration, invasion and cancer metastasis. PKCε has also been implicated in epithelial to mesenchymal transition (EMT), which may be the underlying mechanism by which it contributes to cell motility. In addition, PKCε affects cell-extracellular matrix (ECM) interactions by direct regulation of the cytoskeletal elements. Recent studies have also linked PKCε signaling to cancer stem cell functioning. This review focuses on the role of PKCε in different processes that lead to cancer development and progression. We also discussed current literatures on the pursuit of PKCε as a target for cancer therapy.

AB - The protein kinase C (PKC) family proteins are important signal transducers and have long been the focus of cancer research. PKCε, a member of this family, is overexpressed in most solid tumors and plays critical roles in different processes that lead to cancer development. Studies using cell lines and animal models demonstrated the transforming potential of PKCε. While earlier research established the survival functions of PKCε, recent studies revealed its role in cell migration, invasion and cancer metastasis. PKCε has also been implicated in epithelial to mesenchymal transition (EMT), which may be the underlying mechanism by which it contributes to cell motility. In addition, PKCε affects cell-extracellular matrix (ECM) interactions by direct regulation of the cytoskeletal elements. Recent studies have also linked PKCε signaling to cancer stem cell functioning. This review focuses on the role of PKCε in different processes that lead to cancer development and progression. We also discussed current literatures on the pursuit of PKCε as a target for cancer therapy.

KW - Cancer stem cells

KW - EMT

KW - Metastasis

KW - MicroRNA

KW - PKCε

KW - Survival

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