Abstract
As an iron-chelating agent, deferoxamine (DFO) is widely used in treating iron poisoning and disorders of iron overload. This study demonstrates that DFO is a potent S-phase inhibitor of DNA synthesis in human lymphocytes in vitro, and this inhibitory effect of DFO is reversible by adding appropriate amounts of ferric ion. As a nontoxic and selective-S-phase inhibitor, it may play a role in immunosuppression in experimental and therapeutic situations. It may even become an auxiliary therapy for leukemia or other malignant tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 902-905 |
| Number of pages | 4 |
| Journal | Chinese Medical Journal |
| Volume | 102 |
| Issue number | 12 |
| State | Published - 1 Dec 1989 |