The inhibitory effect of deferoxamine on dna synthesis in human lymphocytes

W. Shu-tong, Kunlin Jin, L. Tian-hong

Research output: Contribution to journalArticle

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Abstract

As an iron-chelating agent, deferoxamine (DFO) is widely used in treating iron poisoning and disorders of iron overload. This study demonstrates that DFO is a potent S-phase inhibitor of DNA synthesis in human lymphocytes in vitro, and this inhibitory effect of DFO is reversible by adding appropriate amounts of ferric ion. As a nontoxic and selective-S-phase inhibitor, it may play a role in immunosuppression in experimental and therapeutic situations. It may even become an auxiliary therapy for leukemia or other malignant tumors.

Original languageEnglish
Pages (from-to)902-905
Number of pages4
JournalChinese Medical Journal
Volume102
Issue number12
StatePublished - 1 Dec 1989

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