Abstract
As an iron-chelating agent, deferoxamine (DFO) is widely used in treating iron poisoning and disorders of iron overload. This study demonstrates that DFO is a potent S-phase inhibitor of DNA synthesis in human lymphocytes in vitro, and this inhibitory effect of DFO is reversible by adding appropriate amounts of ferric ion. As a nontoxic and selective-S-phase inhibitor, it may play a role in immunosuppression in experimental and therapeutic situations. It may even become an auxiliary therapy for leukemia or other malignant tumors.
Original language | English |
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Pages (from-to) | 902-905 |
Number of pages | 4 |
Journal | Chinese Medical Journal |
Volume | 102 |
Issue number | 12 |
State | Published - 1 Dec 1989 |