The inhibition of bovine pancreatic carboxypeptidase a by dihydroxyacetone phosphate

R. C. Adelman, A. G. Lacko

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In a recent study of the effects of various ligands on the rate of proteolytic digestion of rabbit muscle aldolase, it was observed that dihydroxyacetone phosphate (DHAP) acts as a powerful inhibitor of bovine pancreatic carboxypeptidase A (CPA) (Adelman et al., 1968). The present work demonstrates that this inhibition is competitive for both peptidase and esterase activities. Because this represents the first observation of competitive inhibition of CPA by a compound lacking an aromatic group, it was of interest to characterize further the structural requirements for this interaction.

Original languageEnglish
Pages (from-to)596-601
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume33
Issue number4
DOIs
StatePublished - 25 Nov 1968

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