TY - JOUR
T1 - The inheritance of pyloric stenosis explained by a multifactorial threshold model with sex dimorphism for liability
AU - Chakraborty, Ranajit
N1 - Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 1986/1/1
Y1 - 1986/1/1
N2 - The inheritance of pyloric stenosis is explained by a multifactorial threshold model with an underlying assumption that the liability for the disease is distributed in males and females showing a sex dimorphism. From the available data on familial occurrences of pyloric stenosis, it is shown, that an extra maternal effect is not required to explain the familial risk of pyloric stenosis, as opposed to the earlier literature. Explicit expressions for familial risks of a discontinuous trait exhibiting dimorphism of liability are presented, based on a model originally proposed by Rice et al [1981], which do not require the approximation of univariate normality of a conditional bivariate normal distribution.
AB - The inheritance of pyloric stenosis is explained by a multifactorial threshold model with an underlying assumption that the liability for the disease is distributed in males and females showing a sex dimorphism. From the available data on familial occurrences of pyloric stenosis, it is shown, that an extra maternal effect is not required to explain the familial risk of pyloric stenosis, as opposed to the earlier literature. Explicit expressions for familial risks of a discontinuous trait exhibiting dimorphism of liability are presented, based on a model originally proposed by Rice et al [1981], which do not require the approximation of univariate normality of a conditional bivariate normal distribution.
KW - familial risk
KW - maternal effect
KW - multifactorial inheritance
KW - path analysis
KW - pyloric stenosis
KW - sex dimorphism of liability
UR - http://www.scopus.com/inward/record.url?scp=0022620791&partnerID=8YFLogxK
U2 - 10.1002/gepi.1370030102
DO - 10.1002/gepi.1370030102
M3 - Article
C2 - 3957000
AN - SCOPUS:0022620791
SN - 0741-0395
VL - 3
SP - 1
EP - 15
JO - Genetic Epidemiology
JF - Genetic Epidemiology
IS - 1
ER -