The influence of ethnicity and antidepressant pharmacogenetics in the treatment of depression

Michael W. Jann; Lawrence J. Cohen

doi:10.1515/dmdi.2000.16.1.39

The influence of ethnicity and antidepressant pharmacogenetics in the treatment of depression

Michael W. Jann, Lawrence J. Cohen

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Antidepressant disposition can be influenced by a variety of CYP isozymes and their effects in the treatment of depression are reviewed. The CYP isozymes 2D6, 3A4, 1A2 and 2C are discussed in regard to antidepressant drug pharmacokinetics, clinical relevance and variability in activity for each isozyme. Polymorphism has been identified with CYP 2D6 and 2C19. Disposition of antidepressants which are substrates of these two isozymes can also be influenced and contributes towards the wide interpatient and interethnic variability found with these drugs. Antidepressants (especially SSRIs) can be CYP isozyme inhibitors and produce significant drug-drug interactions.

Original language	English
Pages (from-to)	39-67
Number of pages	29
Journal	Drug Metabolism and Drug Interactions
Volume	16
Issue number	1
DOIs	https://doi.org/10.1515/dmdi.2000.16.1.39
State	Published - 2000

Keywords

Antidepressants
CYP isozymes
Drug interactions
Ethnicity
Metabolism

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AB - Antidepressant disposition can be influenced by a variety of CYP isozymes and their effects in the treatment of depression are reviewed. The CYP isozymes 2D6, 3A4, 1A2 and 2C are discussed in regard to antidepressant drug pharmacokinetics, clinical relevance and variability in activity for each isozyme. Polymorphism has been identified with CYP 2D6 and 2C19. Disposition of antidepressants which are substrates of these two isozymes can also be influenced and contributes towards the wide interpatient and interethnic variability found with these drugs. Antidepressants (especially SSRIs) can be CYP isozyme inhibitors and produce significant drug-drug interactions.

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KW - CYP isozymes

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KW - Metabolism

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The influence of ethnicity and antidepressant pharmacogenetics in the treatment of depression

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