The influence of age and sex on the esterification of human serum cholesterol

Andras G. Lacko; H. L. Rutenberg; Louis A. Soloff

doi:10.1016/0006-2944(77)90033-3

The influence of age and sex on the esterification of human serum cholesterol

Andras G. Lacko, H. L. Rutenberg, Louis A. Soloff

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Abstract

Twenty-six male and twenty-four female volunteers were studied with respect to serum-free and total cholesterol, the rate of serum cholesterol esterification, and serum LCAT levels. The rate of serum cholesterol esterification showed a lack of strong correlation with age in both female (r = 0.031) and male (r = 0.26) subjects. Better correlation in both sexes was found between the levels of serum-free cholesterol and the rate of its esterification (r = 0.78 for males, r = 0.5 for females). LCAT enzyme levels also correlated poorly with age in male (r = 0.0424) and in female subjects (r = 0.174). Enzyme levels showed a strong correlation with serum-free cholesterol in male (r = 0.785), but not in female subjects (r = 0.395). Serum cholesterol esterification was significantly higher in males than in females (p < 0.05) and the fractional rate of esterification (percentage of esterification per minute) showed even greater differences between the two sexes (p < 0.001).

Original language	English
Pages (from-to)	275-283
Number of pages	9
Journal	Biochemical medicine
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/0006-2944(77)90033-3
State	Published - Jun 1977

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title = "The influence of age and sex on the esterification of human serum cholesterol",

abstract = "Twenty-six male and twenty-four female volunteers were studied with respect to serum-free and total cholesterol, the rate of serum cholesterol esterification, and serum LCAT levels. The rate of serum cholesterol esterification showed a lack of strong correlation with age in both female (r = 0.031) and male (r = 0.26) subjects. Better correlation in both sexes was found between the levels of serum-free cholesterol and the rate of its esterification (r = 0.78 for males, r = 0.5 for females). LCAT enzyme levels also correlated poorly with age in male (r = 0.0424) and in female subjects (r = 0.174). Enzyme levels showed a strong correlation with serum-free cholesterol in male (r = 0.785), but not in female subjects (r = 0.395). Serum cholesterol esterification was significantly higher in males than in females (p < 0.05) and the fractional rate of esterification (percentage of esterification per minute) showed even greater differences between the two sexes (p < 0.001).",

author = "Lacko, {Andras G.} and Rutenberg, {H. L.} and Soloff, {Louis A.}",

note = "Funding Information: We thank Dr. K. G. Varma for many helpful discussions. Ms. M. J. Nickel and Ms. F. I. Baldwin provided excellent technical assistance and K. Dorr provided secretarial assistance. This research was supported by grants from the Council for Tobacco Research U.S.A., the National Institutes of Health (HL 14924). and 90-A-1050 from the Administration on Aging.",

year = "1977",

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doi = "10.1016/0006-2944(77)90033-3",

language = "English",

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T1 - The influence of age and sex on the esterification of human serum cholesterol

AU - Lacko, Andras G.

AU - Rutenberg, H. L.

AU - Soloff, Louis A.

N1 - Funding Information: We thank Dr. K. G. Varma for many helpful discussions. Ms. M. J. Nickel and Ms. F. I. Baldwin provided excellent technical assistance and K. Dorr provided secretarial assistance. This research was supported by grants from the Council for Tobacco Research U.S.A., the National Institutes of Health (HL 14924). and 90-A-1050 from the Administration on Aging.

PY - 1977/6

Y1 - 1977/6

N2 - Twenty-six male and twenty-four female volunteers were studied with respect to serum-free and total cholesterol, the rate of serum cholesterol esterification, and serum LCAT levels. The rate of serum cholesterol esterification showed a lack of strong correlation with age in both female (r = 0.031) and male (r = 0.26) subjects. Better correlation in both sexes was found between the levels of serum-free cholesterol and the rate of its esterification (r = 0.78 for males, r = 0.5 for females). LCAT enzyme levels also correlated poorly with age in male (r = 0.0424) and in female subjects (r = 0.174). Enzyme levels showed a strong correlation with serum-free cholesterol in male (r = 0.785), but not in female subjects (r = 0.395). Serum cholesterol esterification was significantly higher in males than in females (p < 0.05) and the fractional rate of esterification (percentage of esterification per minute) showed even greater differences between the two sexes (p < 0.001).

AB - Twenty-six male and twenty-four female volunteers were studied with respect to serum-free and total cholesterol, the rate of serum cholesterol esterification, and serum LCAT levels. The rate of serum cholesterol esterification showed a lack of strong correlation with age in both female (r = 0.031) and male (r = 0.26) subjects. Better correlation in both sexes was found between the levels of serum-free cholesterol and the rate of its esterification (r = 0.78 for males, r = 0.5 for females). LCAT enzyme levels also correlated poorly with age in male (r = 0.0424) and in female subjects (r = 0.174). Enzyme levels showed a strong correlation with serum-free cholesterol in male (r = 0.785), but not in female subjects (r = 0.395). Serum cholesterol esterification was significantly higher in males than in females (p < 0.05) and the fractional rate of esterification (percentage of esterification per minute) showed even greater differences between the two sexes (p < 0.001).

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DO - 10.1016/0006-2944(77)90033-3

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VL - 17

SP - 275

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JO - Biochemical medicine

JF - Biochemical medicine

IS - 3

ER -

The influence of age and sex on the esterification of human serum cholesterol

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