The impact on health-related quality of life from non-steroidal anti-inflammatory drugs, methotrexate, or steroids in treatment for juvenile idiopathic arthritis

Russ Riddle; Christina N. Ryser; Anne A. Morton; J. D. Sampson; Richard H. Browne; Marilynn G. Punaro; Robert J. Gatchel

doi:10.1093/jpepsy/jsj014

The impact on health-related quality of life from non-steroidal anti-inflammatory drugs, methotrexate, or steroids in treatment for juvenile idiopathic arthritis

Russ Riddle, Christina N. Ryser, Anne A. Morton, J. D. Sampson, Richard H. Browne, Marilynn G. Punaro, Robert J. Gatchel

Texas College of Osteopathic Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Objective: To assess and compare the impact of medication treatments on health-related quality of life (HRQOL), family function, and medical status in children with juvenile idiopathic arthritis (JIA). Methods: Fifty-seven children diagnosed with JIA were assessed by a pediatric rheumatologist and placed into one of three treatment groups: (1) non-steroidal anti-inflammatory; (2) methotrexate; or (3) steroids via IV methylprednisolone. Questionnaires were administered at baseline and 4-month follow-up. The attending pediatric rheumatologist provided additional medical information. Results: Data document the impact of JIA on HRQOL, particularly on physical and pain domains. Steroid patients experienced improved HRQOL at follow-up relative to other groups, despite reporting more problems with side effects. Conclusion: These results demonstrate positive benefits of steroids in treating JIA children, despite the greatest incidence of adverse side effects.

Original language	English
Pages (from-to)	262-271
Number of pages	10
Journal	Journal of Pediatric Psychology
Volume	31
Issue number	3
DOIs	https://doi.org/10.1093/jpepsy/jsj014
State	Published - Apr 2006

Keywords

Health-related quality of life
Juvenile arthritis
Outcomes

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10.1093/jpepsy/jsj014

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title = "The impact on health-related quality of life from non-steroidal anti-inflammatory drugs, methotrexate, or steroids in treatment for juvenile idiopathic arthritis",

abstract = "Objective: To assess and compare the impact of medication treatments on health-related quality of life (HRQOL), family function, and medical status in children with juvenile idiopathic arthritis (JIA). Methods: Fifty-seven children diagnosed with JIA were assessed by a pediatric rheumatologist and placed into one of three treatment groups: (1) non-steroidal anti-inflammatory; (2) methotrexate; or (3) steroids via IV methylprednisolone. Questionnaires were administered at baseline and 4-month follow-up. The attending pediatric rheumatologist provided additional medical information. Results: Data document the impact of JIA on HRQOL, particularly on physical and pain domains. Steroid patients experienced improved HRQOL at follow-up relative to other groups, despite reporting more problems with side effects. Conclusion: These results demonstrate positive benefits of steroids in treating JIA children, despite the greatest incidence of adverse side effects.",

keywords = "Health-related quality of life, Juvenile arthritis, Outcomes",

author = "Russ Riddle and Ryser, {Christina N.} and Morton, {Anne A.} and Sampson, {J. D.} and Browne, {Richard H.} and Punaro, {Marilynn G.} and Gatchel, {Robert J.}",

year = "2006",

month = apr,

doi = "10.1093/jpepsy/jsj014",

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pages = "262--271",

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AU - Riddle, Russ

AU - Ryser, Christina N.

AU - Morton, Anne A.

AU - Sampson, J. D.

AU - Browne, Richard H.

AU - Punaro, Marilynn G.

AU - Gatchel, Robert J.

PY - 2006/4

Y1 - 2006/4

N2 - Objective: To assess and compare the impact of medication treatments on health-related quality of life (HRQOL), family function, and medical status in children with juvenile idiopathic arthritis (JIA). Methods: Fifty-seven children diagnosed with JIA were assessed by a pediatric rheumatologist and placed into one of three treatment groups: (1) non-steroidal anti-inflammatory; (2) methotrexate; or (3) steroids via IV methylprednisolone. Questionnaires were administered at baseline and 4-month follow-up. The attending pediatric rheumatologist provided additional medical information. Results: Data document the impact of JIA on HRQOL, particularly on physical and pain domains. Steroid patients experienced improved HRQOL at follow-up relative to other groups, despite reporting more problems with side effects. Conclusion: These results demonstrate positive benefits of steroids in treating JIA children, despite the greatest incidence of adverse side effects.

AB - Objective: To assess and compare the impact of medication treatments on health-related quality of life (HRQOL), family function, and medical status in children with juvenile idiopathic arthritis (JIA). Methods: Fifty-seven children diagnosed with JIA were assessed by a pediatric rheumatologist and placed into one of three treatment groups: (1) non-steroidal anti-inflammatory; (2) methotrexate; or (3) steroids via IV methylprednisolone. Questionnaires were administered at baseline and 4-month follow-up. The attending pediatric rheumatologist provided additional medical information. Results: Data document the impact of JIA on HRQOL, particularly on physical and pain domains. Steroid patients experienced improved HRQOL at follow-up relative to other groups, despite reporting more problems with side effects. Conclusion: These results demonstrate positive benefits of steroids in treating JIA children, despite the greatest incidence of adverse side effects.

KW - Health-related quality of life

KW - Juvenile arthritis

KW - Outcomes

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ER -

The impact on health-related quality of life from non-steroidal anti-inflammatory drugs, methotrexate, or steroids in treatment for juvenile idiopathic arthritis

Abstract

Keywords

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