@article{4237c58081dd4e118802a9fac3ca8849,
title = "The impact of comorbid depression-diabetes on proteomic outcomes among community-dwelling Mexican Americans with mild cognitive impairment",
abstract = "Background: Mexican Americans suffer from a disproportionate burden of modifiable risk factors, which may contribute to the health disparities in mild cognitive impairment (MCI) and Alzheimer's disease (AD).Objective: The purpose of this study was to elucidate the impact of comorbid depression and diabetes on proteomic outcomes among community-dwelling Mexican American adults and elders.Methods: Data from participants enrolled in the Health and Aging Brain among Latino Elders study was utilized. Participants were 50 or older and identified as Mexican American (N = 514). Cognition was assessed via neuropsychological test battery and diagnoses of MCI and AD adjudicated by consensus review. The sample was stratified into four groups: Depression only, Neither depression nor diabetes, Diabetes only, and Comorbid depression and diabetes. Proteomic profiles were created via support vector machine analyses.Results: In Mexican Americans, the proteomic profile of MCI may change based upon the presence of diabetes. The profile has a strong inflammatory component and diabetes increases metabolic markers in the profile.Conclusion: Medical comorbidities may impact the proteomics of MCI and AD, which lend support for a precision medicine approach to treating this disease.",
keywords = "Mexican Americans, depression, diabetes mellitus, proteomics",
author = "Johnson, {Leigh Ann} and Fan Zhang and Stephanie Large and James Hall and O'bryant, {Sidney E.}",
note = "Funding Information: Research reported in this publication was supported by the National Institute on Aging under Award Numbers R01AG054073, R01AG051848, R01AG058537, R01AG058252, and R56AG 054073. The National Institutes of Health had no role in the design and conduct of the study: collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Additional support was provided by the Alzheimer's Association NIRG, AARG-16-442652, and the JES Edwards foundation. The study team would like to thank the HABLE study participants and Fort Worth community for supporting this study. Funding Information: Research reported in this publication was supported by the National Institute on Aging under Award Numbers R01AG054073, R01AG051848, R01AG058537, R01AG058252, and R56AG 054073. The National Institutes of Health had no role in the design and conduct of the study: collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Additional support was provided by the Alzheimer{\textquoteright}s Association NIRG, AARG-16-442652, and the JES Edwards foundation. The study team would like to thank the HABLE study participants and Fort Worth community for supporting this study. Publisher Copyright: {\textcopyright} International Psychogeriatric Association 2019.",
year = "2020",
month = jan,
day = "1",
doi = "10.1017/S1041610219001625",
language = "English",
volume = "32",
pages = "17--23",
journal = "International Psychogeriatrics",
issn = "1041-6102",
publisher = "Cambridge University Press",
number = "1",
}