The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron

Hriday Das, C. L. Jackson, D. A. Miller, T. Leff, J. L. Breslow

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

The human apolipoprotein C-II gene was sequenced and found to contain four exons and three introns, with a major transcription initiation site located 26 base pairs downstream from a TATA sequence element. The third intron was found to be composed almost entirely of a novel 37-base pair minisatellite that is repeated six times. The minisatellite sequence was found to be present in approximately 60 different genomic locations. The minisatellite DNA sequence at three of these loci were compared and found to be highly conserved. In situ hybridization indicated that the minisatellite loci were clustered in the q13.3 band of chromosome 19. This is the first example of a chromosome- and band-specific repetitive element in the mammalian genome.

Original languageEnglish
Pages (from-to)4787-4793
Number of pages7
JournalJournal of Biological Chemistry
Volume262
Issue number10
StatePublished - 17 Sep 1987

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