The genomic organisation and nucleotide sequence of the HLA-SB(DP) alpha gene

Simon K. Lawrance, Hriday K. Das, Julian Pan, Sherman M. Weissman

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We have isolated a unique fragment of the HLA-DR alpha gene and probed human genomic DNA at low stringency to search for homologous sequences. A minimum of six non-polymorphic cross-hybridizing high molecular weight fragments were found in all DNAs examined. In order to obtain molecular clones of these cross-hybridizing fragments, we constructed lambda and cosmid libraries of human DNA and screened them at low stringency with the HLA-DR alpha gene specific subclone. We have isolated clones corresponding to each of the six fragments and, in this paper, describe those which contain the gene encoding HLA-SB(DP) alpha.

Original languageEnglish
Pages (from-to)7515-7528
Number of pages14
JournalNucleic Acids Research
Issue number20
Publication statusPublished - 25 Oct 1985


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