Abstract
We have isolated a unique fragment of the HLA-DR alpha gene and probed human genomic DNA at low stringency to search for homologous sequences. A minimum of six non-polymorphic cross-hybridizing high molecular weight fragments were found in all DNAs examined. In order to obtain molecular clones of these cross-hybridizing fragments, we constructed lambda and cosmid libraries of human DNA and screened them at low stringency with the HLA-DR alpha gene specific subclone. We have isolated clones corresponding to each of the six fragments and, in this paper, describe those which contain the gene encoding HLA-SB(DP) alpha.
Original language | English |
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Pages (from-to) | 7515-7528 |
Number of pages | 14 |
Journal | Nucleic Acids Research |
Volume | 13 |
Issue number | 20 |
DOIs | |
State | Published - 25 Oct 1985 |