The genetic structure of native Americans in North America based on the Globalfiler® STRs

Kelly L. McCulloh; Jillian Ng; Robert F. Oldt; Jessica A. Weise; Joy Viray; Bruce Budowle; David Glenn Smith; Sreetharan Kanthaswamy

doi:10.1016/j.legalmed.2016.09.007

The genetic structure of native Americans in North America based on the Globalfiler® STRs

Kelly L. McCulloh, Jillian Ng, Robert F. Oldt, Jessica A. Weise, Joy Viray, Bruce Budowle, David Glenn Smith, Sreetharan Kanthaswamy

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Current forensic STR databases, such as CODIS, lack population genetic data on Native American populations. Information from a geographically diverse array of tribes is necessary to provide improved statistical estimates of the strength of associations with DNA evidence. The Globalfiler® STR markers were used to characterize the genetic structure of ten tribal populations from seven geographic regions in North America, including those not presently represented in forensic databases. Samples from the Arctic region, Baja California, California/Great Basin, the Southeast, Mexico, the Midwest, and the Southwest were analyzed for allele frequencies, observed and expected heterozygosities, and F-statistics. The tribal samples exhibited an F_ST or θ value above the conservative 0.03 estimate recommended by the National Research Council (NRC) for calculating random match probabilities among Native Americans. The greater differentiation among tribal populations computed here (θ = 0.04) warrants the inclusion of additional regional Native American samples into STR databases.

Original language	English
Pages (from-to)	49-54
Number of pages	6
Journal	Legal Medicine
Volume	23
DOIs	https://doi.org/10.1016/j.legalmed.2016.09.007
State	Published - 1 Nov 2016

Keywords

Forensic science
Geography
Native Americans
North America
Population genetics
Short tandem repeats

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title = "The genetic structure of native Americans in North America based on the Globalfiler{\textregistered} STRs",

abstract = "Current forensic STR databases, such as CODIS, lack population genetic data on Native American populations. Information from a geographically diverse array of tribes is necessary to provide improved statistical estimates of the strength of associations with DNA evidence. The Globalfiler{\textregistered} STR markers were used to characterize the genetic structure of ten tribal populations from seven geographic regions in North America, including those not presently represented in forensic databases. Samples from the Arctic region, Baja California, California/Great Basin, the Southeast, Mexico, the Midwest, and the Southwest were analyzed for allele frequencies, observed and expected heterozygosities, and F-statistics. The tribal samples exhibited an FST or θ value above the conservative 0.03 estimate recommended by the National Research Council (NRC) for calculating random match probabilities among Native Americans. The greater differentiation among tribal populations computed here (θ = 0.04) warrants the inclusion of additional regional Native American samples into STR databases.",

keywords = "Forensic science, Geography, Native Americans, North America, Population genetics, Short tandem repeats",

author = "McCulloh, {Kelly L.} and Jillian Ng and Oldt, {Robert F.} and Weise, {Jessica A.} and Joy Viray and Bruce Budowle and {Glenn Smith}, David and Sreetharan Kanthaswamy",

note = "Funding Information: The research described in this article has been reported in Kelly L. McCulloh{\textquoteright}s Masters of Science (Forensic Science) thesis, which will be submitted to the UC Davis Office of Graduate Studies. The authors wish to thank the two anonymous reviewers for their critical review of this manuscript that has resulted in its significant imporvement. This study was supported by a National Institute of Justice – United States grant 2014-DN-BX-K024 to SK and a research grant to KM from the UC Davis Forensic Science Graduate Program . Publisher Copyright: {\textcopyright} 2016",

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AU - Budowle, Bruce

AU - Glenn Smith, David

AU - Kanthaswamy, Sreetharan

N1 - Funding Information: The research described in this article has been reported in Kelly L. McCulloh’s Masters of Science (Forensic Science) thesis, which will be submitted to the UC Davis Office of Graduate Studies. The authors wish to thank the two anonymous reviewers for their critical review of this manuscript that has resulted in its significant imporvement. This study was supported by a National Institute of Justice – United States grant 2014-DN-BX-K024 to SK and a research grant to KM from the UC Davis Forensic Science Graduate Program . Publisher Copyright: © 2016

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N2 - Current forensic STR databases, such as CODIS, lack population genetic data on Native American populations. Information from a geographically diverse array of tribes is necessary to provide improved statistical estimates of the strength of associations with DNA evidence. The Globalfiler® STR markers were used to characterize the genetic structure of ten tribal populations from seven geographic regions in North America, including those not presently represented in forensic databases. Samples from the Arctic region, Baja California, California/Great Basin, the Southeast, Mexico, the Midwest, and the Southwest were analyzed for allele frequencies, observed and expected heterozygosities, and F-statistics. The tribal samples exhibited an FST or θ value above the conservative 0.03 estimate recommended by the National Research Council (NRC) for calculating random match probabilities among Native Americans. The greater differentiation among tribal populations computed here (θ = 0.04) warrants the inclusion of additional regional Native American samples into STR databases.

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The genetic structure of native Americans in North America based on the Globalfiler® STRs

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