### Abstract

For any k allelic autosomal system, a new model involving exactly (k-1) (k+2)/2 independent parameters is proposed and called the generalized Wright's model. The (k-1) (k+2)/2-(k-1) additional parameters, apart from k-1 gene frequencies, are introduced as certain F statisitcs analogous to the so called inbreeding coefficient F. Problems of testing the equality, detection, and estimation of the F statistics are briefly discussed. A composite F statistic, as a function of the various F statistics, is introduced, and the effects of population subdivision on the composite F statistic are studied. The methodology is illustrated using data on the ABO blood group system.

Original language | English |
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Pages (from-to) | 444-453 |

Number of pages | 10 |

Journal | American Journal of Human Genetics |

Volume | 26 |

Issue number | 4 |

State | Published - 1974 |

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## Cite this

Rao, D. C., & Chakraborty, R. (1974). The generalized Wright's model and population structure with special reference to the ABO blood group system.

*American Journal of Human Genetics*,*26*(4), 444-453.