The generalized Wright's model and population structure with special reference to the ABO blood group system

D. C. Rao, Ranajit Chakraborty

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Abstract

For any k allelic autosomal system, a new model involving exactly (k-1) (k+2)/2 independent parameters is proposed and called the generalized Wright's model. The (k-1) (k+2)/2-(k-1) additional parameters, apart from k-1 gene frequencies, are introduced as certain F statisitcs analogous to the so called inbreeding coefficient F. Problems of testing the equality, detection, and estimation of the F statistics are briefly discussed. A composite F statistic, as a function of the various F statistics, is introduced, and the effects of population subdivision on the composite F statistic are studied. The methodology is illustrated using data on the ABO blood group system.

Original languageEnglish
Pages (from-to)444-453
Number of pages10
JournalAmerican Journal of Human Genetics
Volume26
Issue number4
Publication statusPublished - 1 Dec 1974

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