### Abstract

For any k allelic autosomal system, a new model involving exactly (k-1) (k+2)/2 independent parameters is proposed and called the generalized Wright's model. The (k-1) (k+2)/2-(k-1) additional parameters, apart from k-1 gene frequencies, are introduced as certain F statisitcs analogous to the so called inbreeding coefficient F. Problems of testing the equality, detection, and estimation of the F statistics are briefly discussed. A composite F statistic, as a function of the various F statistics, is introduced, and the effects of population subdivision on the composite F statistic are studied. The methodology is illustrated using data on the ABO blood group system.

Original language | English |
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Pages (from-to) | 444-453 |

Number of pages | 10 |

Journal | American Journal of Human Genetics |

Volume | 26 |

Issue number | 4 |

State | Published - 1 Dec 1974 |

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### Cite this

*American Journal of Human Genetics*,

*26*(4), 444-453.

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*American Journal of Human Genetics*, vol. 26, no. 4, pp. 444-453.

**The generalized Wright's model and population structure with special reference to the ABO blood group system.** / Rao, D. C.; Chakraborty, Ranajit.

Research output: Contribution to journal › Article

TY - JOUR

T1 - The generalized Wright's model and population structure with special reference to the ABO blood group system

AU - Rao, D. C.

AU - Chakraborty, Ranajit

PY - 1974/12/1

Y1 - 1974/12/1

N2 - For any k allelic autosomal system, a new model involving exactly (k-1) (k+2)/2 independent parameters is proposed and called the generalized Wright's model. The (k-1) (k+2)/2-(k-1) additional parameters, apart from k-1 gene frequencies, are introduced as certain F statisitcs analogous to the so called inbreeding coefficient F. Problems of testing the equality, detection, and estimation of the F statistics are briefly discussed. A composite F statistic, as a function of the various F statistics, is introduced, and the effects of population subdivision on the composite F statistic are studied. The methodology is illustrated using data on the ABO blood group system.

AB - For any k allelic autosomal system, a new model involving exactly (k-1) (k+2)/2 independent parameters is proposed and called the generalized Wright's model. The (k-1) (k+2)/2-(k-1) additional parameters, apart from k-1 gene frequencies, are introduced as certain F statisitcs analogous to the so called inbreeding coefficient F. Problems of testing the equality, detection, and estimation of the F statistics are briefly discussed. A composite F statistic, as a function of the various F statistics, is introduced, and the effects of population subdivision on the composite F statistic are studied. The methodology is illustrated using data on the ABO blood group system.

UR - http://www.scopus.com/inward/record.url?scp=0016257091&partnerID=8YFLogxK

M3 - Article

C2 - 4842772

AN - SCOPUS:0016257091

VL - 26

SP - 444

EP - 453

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

SN - 0002-9297

IS - 4

ER -