The future of blood-based biomarkers for Alzheimer's disease

Kim Henriksen, Sid E. O'Bryant, Harald Hampel, John Q. Trojanowski, Thomas J. Montine, Andreas Jeromin, Kaj Blennow, Anders Lönneborg, Tony Wyss-Coray, Holly Soares, Chantal Bazenet, Magnus Sjögren, William Hu, Simon Lovestone, Morten A. Karsdal, Michael W. Weiner

Research output: Contribution to journalReview article

157 Scopus citations

Abstract

Treatment of Alzheimer's disease (AD) is significantly hampered by the lack of easily accessible biomarkers that can detect disease presence and predict disease risk reliably. Fluid biomarkers of AD currently provide indications of disease stage; however, they are not robust predictors of disease progression or treatment response, and most are measured in cerebrospinal fluid, which limits their applicability. With these aspects in mind, the aim of this article is to underscore the concerted efforts of the Blood-Based Biomarker Interest Group, an international working group of experts in the field. The points addressed include: (1) the major challenges in the development of blood-based biomarkers of AD, including patient heterogeneity, inclusion of the "right" control population, and the blood-brain barrier; (2) the need for a clear definition of the purpose of the individual markers (e.g., prognostic, diagnostic, or monitoring therapeutic efficacy); (3) a critical evaluation of the ongoing biomarker approaches; and (4) highlighting the need for standardization of preanalytical variables and analytical methodologies used by the field.

Original languageEnglish
Pages (from-to)115-131
Number of pages17
JournalAlzheimer's and Dementia
Volume10
Issue number1
DOIs
StatePublished - 1 Jan 2014

Keywords

  • Alzheimer's disease
  • Biomarkers
  • Blood
  • Plasma
  • Serum

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    Henriksen, K., O'Bryant, S. E., Hampel, H., Trojanowski, J. Q., Montine, T. J., Jeromin, A., Blennow, K., Lönneborg, A., Wyss-Coray, T., Soares, H., Bazenet, C., Sjögren, M., Hu, W., Lovestone, S., Karsdal, M. A., & Weiner, M. W. (2014). The future of blood-based biomarkers for Alzheimer's disease. Alzheimer's and Dementia, 10(1), 115-131. https://doi.org/10.1016/j.jalz.2013.01.013