The factor C3 conversion in human complement by smooth Shigella flexneri lipopolysaccharides

Rafał Fudała, Włodzimierz Doroszkiewicz, Joanna Niedbach, Andrzej Gamian, Andrej Weintraub, Wiesław Kaca

Research output: Contribution to journalArticlepeer-review

Abstract

Shigella flexneri rods play an important role in human intestinal infections. In the presented studies we have shown that O-acetyl and glucose residues, substituted in main GalNAc-Rha chains of lipopolysaccharide (LPS) are important for the bactericidal effect of human serum. By dot-blot, immunoblotting and ELISA with immobilized LPS we have shown correlation of C3 fragments deposition and serum resistance. LPSs isolated from a serum-sensitive strain deposited more C3 fragments than LPSs from serum-resistant Shigella flexneri strains.

Original languageEnglish
Pages (from-to)45-52
Number of pages8
JournalActa Microbiologica Polonica
Volume52
Issue number1
StatePublished - 6 May 2003

Keywords

  • C3 fragments
  • Complement
  • Lipopolysacharide
  • Shigella flexneri

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