The factor C3 conversion in human complement by smooth Shigella flexneri lipopolysaccharides

Rafał Fudała; Włodzimierz Doroszkiewicz; Joanna Niedbach; Andrzej Gamian; Andrej Weintraub; Wiesław Kaca

The factor C3 conversion in human complement by smooth Shigella flexneri lipopolysaccharides

Rafał Fudała, Włodzimierz Doroszkiewicz, Joanna Niedbach, Andrzej Gamian, Andrej Weintraub, Wiesław Kaca

Research output: Contribution to journal › Article › peer-review

Abstract

Shigella flexneri rods play an important role in human intestinal infections. In the presented studies we have shown that O-acetyl and glucose residues, substituted in main GalNAc-Rha chains of lipopolysaccharide (LPS) are important for the bactericidal effect of human serum. By dot-blot, immunoblotting and ELISA with immobilized LPS we have shown correlation of C3 fragments deposition and serum resistance. LPSs isolated from a serum-sensitive strain deposited more C3 fragments than LPSs from serum-resistant Shigella flexneri strains.

Original language	English
Pages (from-to)	45-52
Number of pages	8
Journal	Acta Microbiologica Polonica
Volume	52
Issue number	1
State	Published - 2003

Keywords

C3 fragments
Complement
Lipopolysacharide
Shigella flexneri

Cite this

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abstract = "Shigella flexneri rods play an important role in human intestinal infections. In the presented studies we have shown that O-acetyl and glucose residues, substituted in main GalNAc-Rha chains of lipopolysaccharide (LPS) are important for the bactericidal effect of human serum. By dot-blot, immunoblotting and ELISA with immobilized LPS we have shown correlation of C3 fragments deposition and serum resistance. LPSs isolated from a serum-sensitive strain deposited more C3 fragments than LPSs from serum-resistant Shigella flexneri strains.",

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T1 - The factor C3 conversion in human complement by smooth Shigella flexneri lipopolysaccharides

AU - Fudała, Rafał

AU - Doroszkiewicz, Włodzimierz

AU - Niedbach, Joanna

AU - Gamian, Andrzej

AU - Weintraub, Andrej

AU - Kaca, Wiesław

PY - 2003

Y1 - 2003

N2 - Shigella flexneri rods play an important role in human intestinal infections. In the presented studies we have shown that O-acetyl and glucose residues, substituted in main GalNAc-Rha chains of lipopolysaccharide (LPS) are important for the bactericidal effect of human serum. By dot-blot, immunoblotting and ELISA with immobilized LPS we have shown correlation of C3 fragments deposition and serum resistance. LPSs isolated from a serum-sensitive strain deposited more C3 fragments than LPSs from serum-resistant Shigella flexneri strains.

AB - Shigella flexneri rods play an important role in human intestinal infections. In the presented studies we have shown that O-acetyl and glucose residues, substituted in main GalNAc-Rha chains of lipopolysaccharide (LPS) are important for the bactericidal effect of human serum. By dot-blot, immunoblotting and ELISA with immobilized LPS we have shown correlation of C3 fragments deposition and serum resistance. LPSs isolated from a serum-sensitive strain deposited more C3 fragments than LPSs from serum-resistant Shigella flexneri strains.

KW - C3 fragments

KW - Complement

KW - Lipopolysacharide

KW - Shigella flexneri

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M3 - Article

C2 - 12916727

AN - SCOPUS:0346997040

SN - 0137-1320

VL - 52

SP - 45

EP - 52

JO - Acta Microbiologica Polonica

JF - Acta Microbiologica Polonica

IS - 1

ER -

The factor C3 conversion in human complement by smooth Shigella flexneri lipopolysaccharides

Abstract

Keywords

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