The evaluation of an autosomal SNP 12-plex assay

P. M. Vallone; A. E. Decker; M. D. Coble; J. M. Butler

doi:10.1016/j.ics.2005.11.039

The evaluation of an autosomal SNP 12-plex assay

P. M. Vallone, A. E. Decker, M. D. Coble, J. M. Butler

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

SNPs have the potential to play a useful role in human identification testing. Small PCR amplicon sizes associated with SNP typing technologies make SNPs attractive for typing degraded DNA or other low copy number situations. SNP markers can be useful in combination with STRs for resolving complex paternity issues (e.g. incest), identifying victims of mass disasters where insufficient family references are available and possibly inferring population of origin. Important considerations for SNP markers are the larger number required to equal the discriminatory power compared to traditional STRs, their inability to resolve complex mixtures, issues related to databasing new loci and the availability of a standard analysis platform.

Original language	English
Pages (from-to)	61-63
Number of pages	3
Journal	International Congress Series
Volume	1288
DOIs	https://doi.org/10.1016/j.ics.2005.11.039
State	Published - Apr 2006

Keywords

Allele specific primer extension
Autosomal marker
Multiplex PCR
NIST
SNP

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10.1016/j.ics.2005.11.039

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AB - SNPs have the potential to play a useful role in human identification testing. Small PCR amplicon sizes associated with SNP typing technologies make SNPs attractive for typing degraded DNA or other low copy number situations. SNP markers can be useful in combination with STRs for resolving complex paternity issues (e.g. incest), identifying victims of mass disasters where insufficient family references are available and possibly inferring population of origin. Important considerations for SNP markers are the larger number required to equal the discriminatory power compared to traditional STRs, their inability to resolve complex mixtures, issues related to databasing new loci and the availability of a standard analysis platform.

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The evaluation of an autosomal SNP 12-plex assay

Abstract

Keywords

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