The enigmatic protein kinase C-eta

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Protein kinase C (PKC), a multi-gene family, plays critical roles in signal transduction and cell regulation. Protein kinase C-eta (PKCη) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCη was shown to regulate cell proliferation, differentiation and cell death. It was also shown to contribute to chemoresistance in several cancers. PKCη has been associated with several cancers, including renal cell carcinoma, glioblastoma, breast cancer, non-small cell lung cancer, and acute myeloid leukemia. However, mice lacking PKCη were more susceptible to tumor formation in a two-stage carcinogenesis model, and it is downregulated in hepatocellular carcinoma. Thus, the role of PKCη in cancer remains controversial. The purpose of this review article is to discuss how PKCη regulates various cellular processes that may contribute to its contrasting roles in cancer.

Original languageEnglish
Article number214
JournalCancers
Volume11
Issue number2
DOIs
StatePublished - 1 Feb 2019

Fingerprint

Protein Kinase C
Neoplasms
protein kinase C eta
Glioblastoma
Renal Cell Carcinoma
Acute Myeloid Leukemia
Non-Small Cell Lung Carcinoma
Isoenzymes
Cell Differentiation
Hepatocellular Carcinoma
Signal Transduction
Carcinogenesis
Cell Death
Down-Regulation
Cell Proliferation
Breast Neoplasms
Genes

Keywords

  • Apoptosis
  • Cell proliferation
  • Differentiation
  • Drug resistance
  • PKCη
  • Protein kinase C
  • Senescence
  • Tumor promotion
  • Tumor suppression

Cite this

@article{960e918d86b543ce830318bb380f8549,
title = "The enigmatic protein kinase C-eta",
abstract = "Protein kinase C (PKC), a multi-gene family, plays critical roles in signal transduction and cell regulation. Protein kinase C-eta (PKCη) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCη was shown to regulate cell proliferation, differentiation and cell death. It was also shown to contribute to chemoresistance in several cancers. PKCη has been associated with several cancers, including renal cell carcinoma, glioblastoma, breast cancer, non-small cell lung cancer, and acute myeloid leukemia. However, mice lacking PKCη were more susceptible to tumor formation in a two-stage carcinogenesis model, and it is downregulated in hepatocellular carcinoma. Thus, the role of PKCη in cancer remains controversial. The purpose of this review article is to discuss how PKCη regulates various cellular processes that may contribute to its contrasting roles in cancer.",
keywords = "Apoptosis, Cell proliferation, Differentiation, Drug resistance, PKCη, Protein kinase C, Senescence, Tumor promotion, Tumor suppression",
author = "Alakananda Basu",
year = "2019",
month = "2",
day = "1",
doi = "10.3390/cancers11020214",
language = "English",
volume = "11",
journal = "Cancers",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",

}

The enigmatic protein kinase C-eta. / Basu, Alakananda.

In: Cancers, Vol. 11, No. 2, 214, 01.02.2019.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - The enigmatic protein kinase C-eta

AU - Basu, Alakananda

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Protein kinase C (PKC), a multi-gene family, plays critical roles in signal transduction and cell regulation. Protein kinase C-eta (PKCη) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCη was shown to regulate cell proliferation, differentiation and cell death. It was also shown to contribute to chemoresistance in several cancers. PKCη has been associated with several cancers, including renal cell carcinoma, glioblastoma, breast cancer, non-small cell lung cancer, and acute myeloid leukemia. However, mice lacking PKCη were more susceptible to tumor formation in a two-stage carcinogenesis model, and it is downregulated in hepatocellular carcinoma. Thus, the role of PKCη in cancer remains controversial. The purpose of this review article is to discuss how PKCη regulates various cellular processes that may contribute to its contrasting roles in cancer.

AB - Protein kinase C (PKC), a multi-gene family, plays critical roles in signal transduction and cell regulation. Protein kinase C-eta (PKCη) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCη was shown to regulate cell proliferation, differentiation and cell death. It was also shown to contribute to chemoresistance in several cancers. PKCη has been associated with several cancers, including renal cell carcinoma, glioblastoma, breast cancer, non-small cell lung cancer, and acute myeloid leukemia. However, mice lacking PKCη were more susceptible to tumor formation in a two-stage carcinogenesis model, and it is downregulated in hepatocellular carcinoma. Thus, the role of PKCη in cancer remains controversial. The purpose of this review article is to discuss how PKCη regulates various cellular processes that may contribute to its contrasting roles in cancer.

KW - Apoptosis

KW - Cell proliferation

KW - Differentiation

KW - Drug resistance

KW - PKCη

KW - Protein kinase C

KW - Senescence

KW - Tumor promotion

KW - Tumor suppression

UR - http://www.scopus.com/inward/record.url?scp=85062431380&partnerID=8YFLogxK

U2 - 10.3390/cancers11020214

DO - 10.3390/cancers11020214

M3 - Review article

VL - 11

JO - Cancers

JF - Cancers

SN - 2072-6694

IS - 2

M1 - 214

ER -