TY - CHAP
T1 - The Endocrine Kidney
T2 - Local and Systemic Actions of Renal Hormones
AU - Mallet, Robert T.
AU - Ma, Rong
N1 - Funding Information:
While completing this work Dr. Ma was supported by grants 1-R01-DK-115424 from the U.S. National Institute of Diabetes and Digestive and Kidney Diseases and 16GRNT27780043 from American Heart Association Southwest Affiliate, and Dr. Mallet by grants from the Institute for Cardiovascular and Metabolic Diseases and the Office of Research and Innovation, University of North Texas Health Science Center.
Publisher Copyright:
© 2020 Elsevier Inc. All rights reserved.
PY - 2019/10/23
Y1 - 2019/10/23
N2 - The myriad physiologic functions of the kidneys are heavily regulated by the endocrine system. While extrarenal hormones exert well-recognized actions in the urinary system, in recent decades a host of intrinsic, renal hormones, with powerful effects on renal hemodynamics, glomerular filtration, and tubular electrolyte and water handling has been identified. Renal microcirculation, glomerular mesangium, and tubular epithelium produce angiotensin II, the natriuretic peptide urodilatin, vasoconstrictors endothelin-1 and urotensin II, and vasodilators adrenomedullin and intermedin. In addition, new details are emerging regarding the complex regulation of renal calcitriol production. The hematopoietic renal hormone erythropoietin has been found to mitigate ischemic injury to the kidneys, heart, and central nervous system. This chapter presents these products of the endocrine kidney and discusses their renal and systemic physiologic functions, their beneficial versus maladaptive contributions to renal diseases, and their potential exploitation to treat clinical disorders of the kidneys and other organs.
AB - The myriad physiologic functions of the kidneys are heavily regulated by the endocrine system. While extrarenal hormones exert well-recognized actions in the urinary system, in recent decades a host of intrinsic, renal hormones, with powerful effects on renal hemodynamics, glomerular filtration, and tubular electrolyte and water handling has been identified. Renal microcirculation, glomerular mesangium, and tubular epithelium produce angiotensin II, the natriuretic peptide urodilatin, vasoconstrictors endothelin-1 and urotensin II, and vasodilators adrenomedullin and intermedin. In addition, new details are emerging regarding the complex regulation of renal calcitriol production. The hematopoietic renal hormone erythropoietin has been found to mitigate ischemic injury to the kidneys, heart, and central nervous system. This chapter presents these products of the endocrine kidney and discusses their renal and systemic physiologic functions, their beneficial versus maladaptive contributions to renal diseases, and their potential exploitation to treat clinical disorders of the kidneys and other organs.
KW - Adrenomedullin
KW - Calcitriol
KW - Endothelin
KW - Erythropoietin
KW - Intermedin
KW - Natriuretic peptide
KW - Renin
KW - Urodilatin
KW - Urotensin
UR - http://www.scopus.com/inward/record.url?scp=85083753343&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-813814-4.00019-5
DO - 10.1016/B978-0-12-813814-4.00019-5
M3 - Chapter
AN - SCOPUS:85083753343
SN - 9780128138144
SP - 445
EP - 460
BT - Hormonal Signaling in Biology and Medicine
PB - Elsevier
ER -