The effects of methylmercury compounds on the skin (in vitro) of the leopard frog (Rana pipiens)

Thomas Yorio, P. J. Bentley

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

1. 1. Leopard frogs readily survive injections of large amounts of dimethylmercury or methylmercuric chloride. 2. 2. The short-circuit current and P.D. across the skin (in vitro) were not changed by dimethylmercury (10-3 M) but were reduced by methylmercuric chloride (10-4 M). The latter was only active when present in the epidermal bathing media. 3. 3. The electrical resistance rose initially, then declined. 4. 4. These responses were only modified when BAL was added prior to the drug. The effects were irreversible. 5. 5. The action of vasotocin on osmotic water transfer was antagonized by methyl-mercuric chloride and the O2 consumption was depressed. Dimethylmercury (10-3 M) was without action.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalComparative and General Pharmacology
Volume4
Issue number14
DOIs
StatePublished - 1 Jan 1973

Fingerprint

Methylmercury Compounds
Rana pipiens
Skin
Methyl Chloride
Vasotocin
Dimercaprol
Mercuric Chloride
Electric Impedance
Injections
Water
Pharmaceutical Preparations
dimethyl mercury
In Vitro Techniques
methylmercuric chloride

Keywords

  • Rana pipiens
  • Short-circuit current
  • dimethyl mercury
  • frog skin
  • mercuric salts
  • methylmercuric chloride
  • vasotocin

Cite this

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The effects of methylmercury compounds on the skin (in vitro) of the leopard frog (Rana pipiens). / Yorio, Thomas; Bentley, P. J.

In: Comparative and General Pharmacology, Vol. 4, No. 14, 01.01.1973, p. 167-174.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The effects of methylmercury compounds on the skin (in vitro) of the leopard frog (Rana pipiens)

AU - Yorio, Thomas

AU - Bentley, P. J.

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N2 - 1. 1. Leopard frogs readily survive injections of large amounts of dimethylmercury or methylmercuric chloride. 2. 2. The short-circuit current and P.D. across the skin (in vitro) were not changed by dimethylmercury (10-3 M) but were reduced by methylmercuric chloride (10-4 M). The latter was only active when present in the epidermal bathing media. 3. 3. The electrical resistance rose initially, then declined. 4. 4. These responses were only modified when BAL was added prior to the drug. The effects were irreversible. 5. 5. The action of vasotocin on osmotic water transfer was antagonized by methyl-mercuric chloride and the O2 consumption was depressed. Dimethylmercury (10-3 M) was without action.

AB - 1. 1. Leopard frogs readily survive injections of large amounts of dimethylmercury or methylmercuric chloride. 2. 2. The short-circuit current and P.D. across the skin (in vitro) were not changed by dimethylmercury (10-3 M) but were reduced by methylmercuric chloride (10-4 M). The latter was only active when present in the epidermal bathing media. 3. 3. The electrical resistance rose initially, then declined. 4. 4. These responses were only modified when BAL was added prior to the drug. The effects were irreversible. 5. 5. The action of vasotocin on osmotic water transfer was antagonized by methyl-mercuric chloride and the O2 consumption was depressed. Dimethylmercury (10-3 M) was without action.

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KW - mercuric salts

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