The effects of methylmercury compounds on the skin (in vitro) of the leopard frog (Rana pipiens)

T. Yorio; P. J. Bentley

doi:10.1016/0010-4035(73)90035-9

The effects of methylmercury compounds on the skin (in vitro) of the leopard frog (Rana pipiens)

T. Yorio, P. J. Bentley

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3 Scopus citations

Abstract

1. 1. Leopard frogs readily survive injections of large amounts of dimethylmercury or methylmercuric chloride. 2. 2. The short-circuit current and P.D. across the skin (in vitro) were not changed by dimethylmercury (10^-3 M) but were reduced by methylmercuric chloride (10^-4 M). The latter was only active when present in the epidermal bathing media. 3. 3. The electrical resistance rose initially, then declined. 4. 4. These responses were only modified when BAL was added prior to the drug. The effects were irreversible. 5. 5. The action of vasotocin on osmotic water transfer was antagonized by methyl-mercuric chloride and the O₂ consumption was depressed. Dimethylmercury (10^-3 M) was without action.

Original language	English
Pages (from-to)	167-174
Number of pages	8
Journal	Comparative and General Pharmacology
Volume	4
Issue number	14
DOIs	https://doi.org/10.1016/0010-4035(73)90035-9
State	Published - Jun 1973

Keywords

Rana pipiens
Short-circuit current
dimethyl mercury
frog skin
mercuric salts
methylmercuric chloride
vasotocin

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10.1016/0010-4035(73)90035-9

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title = "The effects of methylmercury compounds on the skin (in vitro) of the leopard frog (Rana pipiens)",

abstract = "1. 1. Leopard frogs readily survive injections of large amounts of dimethylmercury or methylmercuric chloride. 2. 2. The short-circuit current and P.D. across the skin (in vitro) were not changed by dimethylmercury (10-3 M) but were reduced by methylmercuric chloride (10-4 M). The latter was only active when present in the epidermal bathing media. 3. 3. The electrical resistance rose initially, then declined. 4. 4. These responses were only modified when BAL was added prior to the drug. The effects were irreversible. 5. 5. The action of vasotocin on osmotic water transfer was antagonized by methyl-mercuric chloride and the O2 consumption was depressed. Dimethylmercury (10-3 M) was without action.",

keywords = "Rana pipiens, Short-circuit current, dimethyl mercury, frog skin, mercuric salts, methylmercuric chloride, vasotocin",

author = "T. Yorio and Bentley, {P. J.}",

note = "Funding Information: ACKNOWLEDGEMENTS Mr. T. Yorio is the recipient of a Mount Sinai Graduate School Fellowship. This research was supported by National Science Foundation Grant No. GB-28543X. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1973",

month = jun,

doi = "10.1016/0010-4035(73)90035-9",

language = "English",

volume = "4",

pages = "167--174",

journal = "Comparative and General Pharmacology",

issn = "0010-4035",

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TY - JOUR

T1 - The effects of methylmercury compounds on the skin (in vitro) of the leopard frog (Rana pipiens)

AU - Yorio, T.

AU - Bentley, P. J.

N1 - Funding Information: ACKNOWLEDGEMENTS Mr. T. Yorio is the recipient of a Mount Sinai Graduate School Fellowship. This research was supported by National Science Foundation Grant No. GB-28543X. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1973/6

Y1 - 1973/6

N2 - 1. 1. Leopard frogs readily survive injections of large amounts of dimethylmercury or methylmercuric chloride. 2. 2. The short-circuit current and P.D. across the skin (in vitro) were not changed by dimethylmercury (10-3 M) but were reduced by methylmercuric chloride (10-4 M). The latter was only active when present in the epidermal bathing media. 3. 3. The electrical resistance rose initially, then declined. 4. 4. These responses were only modified when BAL was added prior to the drug. The effects were irreversible. 5. 5. The action of vasotocin on osmotic water transfer was antagonized by methyl-mercuric chloride and the O2 consumption was depressed. Dimethylmercury (10-3 M) was without action.

AB - 1. 1. Leopard frogs readily survive injections of large amounts of dimethylmercury or methylmercuric chloride. 2. 2. The short-circuit current and P.D. across the skin (in vitro) were not changed by dimethylmercury (10-3 M) but were reduced by methylmercuric chloride (10-4 M). The latter was only active when present in the epidermal bathing media. 3. 3. The electrical resistance rose initially, then declined. 4. 4. These responses were only modified when BAL was added prior to the drug. The effects were irreversible. 5. 5. The action of vasotocin on osmotic water transfer was antagonized by methyl-mercuric chloride and the O2 consumption was depressed. Dimethylmercury (10-3 M) was without action.

KW - Rana pipiens

KW - Short-circuit current

KW - dimethyl mercury

KW - frog skin

KW - mercuric salts

KW - methylmercuric chloride

KW - vasotocin

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U2 - 10.1016/0010-4035(73)90035-9

DO - 10.1016/0010-4035(73)90035-9

M3 - Article

C2 - 4543836

AN - SCOPUS:49549161865

VL - 4

SP - 167

EP - 174

JO - Comparative and General Pharmacology

JF - Comparative and General Pharmacology

SN - 0010-4035

IS - 14

ER -

The effects of methylmercury compounds on the skin (in vitro) of the leopard frog (Rana pipiens)

Abstract

Keywords

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