Abstract
1. 1. Leopard frogs readily survive injections of large amounts of dimethylmercury or methylmercuric chloride. 2. 2. The short-circuit current and P.D. across the skin (in vitro) were not changed by dimethylmercury (10-3 M) but were reduced by methylmercuric chloride (10-4 M). The latter was only active when present in the epidermal bathing media. 3. 3. The electrical resistance rose initially, then declined. 4. 4. These responses were only modified when BAL was added prior to the drug. The effects were irreversible. 5. 5. The action of vasotocin on osmotic water transfer was antagonized by methyl-mercuric chloride and the O2 consumption was depressed. Dimethylmercury (10-3 M) was without action.
| Original language | English |
|---|---|
| Pages (from-to) | 167-174 |
| Number of pages | 8 |
| Journal | Comparative and General Pharmacology |
| Volume | 4 |
| Issue number | 14 |
| DOIs | |
| State | Published - 1 Jan 1973 |
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Keywords
- Rana pipiens
- Short-circuit current
- dimethyl mercury
- frog skin
- mercuric salts
- methylmercuric chloride
- vasotocin
Cite this
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The effects of methylmercury compounds on the skin (in vitro) of the leopard frog (Rana pipiens). / Yorio, Thomas; Bentley, P. J.
In: Comparative and General Pharmacology, Vol. 4, No. 14, 01.01.1973, p. 167-174.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - The effects of methylmercury compounds on the skin (in vitro) of the leopard frog (Rana pipiens)
AU - Yorio, Thomas
AU - Bentley, P. J.
PY - 1973/1/1
Y1 - 1973/1/1
N2 - 1. 1. Leopard frogs readily survive injections of large amounts of dimethylmercury or methylmercuric chloride. 2. 2. The short-circuit current and P.D. across the skin (in vitro) were not changed by dimethylmercury (10-3 M) but were reduced by methylmercuric chloride (10-4 M). The latter was only active when present in the epidermal bathing media. 3. 3. The electrical resistance rose initially, then declined. 4. 4. These responses were only modified when BAL was added prior to the drug. The effects were irreversible. 5. 5. The action of vasotocin on osmotic water transfer was antagonized by methyl-mercuric chloride and the O2 consumption was depressed. Dimethylmercury (10-3 M) was without action.
AB - 1. 1. Leopard frogs readily survive injections of large amounts of dimethylmercury or methylmercuric chloride. 2. 2. The short-circuit current and P.D. across the skin (in vitro) were not changed by dimethylmercury (10-3 M) but were reduced by methylmercuric chloride (10-4 M). The latter was only active when present in the epidermal bathing media. 3. 3. The electrical resistance rose initially, then declined. 4. 4. These responses were only modified when BAL was added prior to the drug. The effects were irreversible. 5. 5. The action of vasotocin on osmotic water transfer was antagonized by methyl-mercuric chloride and the O2 consumption was depressed. Dimethylmercury (10-3 M) was without action.
KW - Rana pipiens
KW - Short-circuit current
KW - dimethyl mercury
KW - frog skin
KW - mercuric salts
KW - methylmercuric chloride
KW - vasotocin
UR - http://www.scopus.com/inward/record.url?scp=49549161865&partnerID=8YFLogxK
U2 - 10.1016/0010-4035(73)90035-9
DO - 10.1016/0010-4035(73)90035-9
M3 - Article
VL - 4
SP - 167
EP - 174
JO - Comparative and General Pharmacology
JF - Comparative and General Pharmacology
SN - 0010-4035
IS - 14
ER -