The effects of methylmercury compounds on the skin (in vitro) of the leopard frog (Rana pipiens)

T. Yorio, P. J. Bentley

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

1. 1. Leopard frogs readily survive injections of large amounts of dimethylmercury or methylmercuric chloride. 2. 2. The short-circuit current and P.D. across the skin (in vitro) were not changed by dimethylmercury (10-3 M) but were reduced by methylmercuric chloride (10-4 M). The latter was only active when present in the epidermal bathing media. 3. 3. The electrical resistance rose initially, then declined. 4. 4. These responses were only modified when BAL was added prior to the drug. The effects were irreversible. 5. 5. The action of vasotocin on osmotic water transfer was antagonized by methyl-mercuric chloride and the O2 consumption was depressed. Dimethylmercury (10-3 M) was without action.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalComparative and General Pharmacology
Volume4
Issue number14
DOIs
StatePublished - Jun 1973

Keywords

  • Rana pipiens
  • Short-circuit current
  • dimethyl mercury
  • frog skin
  • mercuric salts
  • methylmercuric chloride
  • vasotocin

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