The Effects of Endocrine Disruptors on Mesenchymal Stem Cells

Marjorie E. Bateman, Amy L. Strong, John McLachlan, Matthew E. Burow, Bruce A. Bunnell

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Endocrine disrupting compounds (EDCs) are a growing area of research in toxicology as these compounds impact human health and disease. One explanation for the rapid rise in prevalence of diseases such as obesity and diabetes mellitus is the exposure to EDCs. EDCs may have the capacity to disrupt vital aspects of multipotent mesenchymal stromal cell or mesenchymal stem cell (MSC) and MSC lineage cell function in the body, including the ability of MSCs to proliferate, to differentiate, and to maintain body homeostasis. Salient information regarding MSC characterization, differentiation, function, and aging will be addressed. This chapter will cover effects of EDCs including organophosphate pesticides, DDT, alkylphenols, bisphenol A (BPA), polychlorinated biphenyls (PCBs), and phthalates on MSCs and the adipocytic and osteoblastic lineage of MSCs in addition to general molecular effects of these compounds. The effects of EDCs on MSCs, particularly the adipocytic lineage of MSCs, may explain the EDC role in inducing development of chronic diseases such as obesity and diabetes mellitus.

Original languageEnglish
Title of host publicationStem Cells in Toxicology and Medicine
Publisherwiley
Pages196-237
Number of pages42
ISBN (Electronic)9781119135449
ISBN (Print)9781119135418
DOIs
StatePublished - 28 Dec 2016

Keywords

  • Adipogenesis
  • Bisphenol A
  • DDT
  • Endocrine disruptors
  • Mesenchymal stem cells
  • Nonylphenol
  • Obesity
  • Octylphenol
  • Organophosphates
  • Phthalic acids
  • Polychlorinated biphenyls

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  • Cite this

    Bateman, M. E., Strong, A. L., McLachlan, J., Burow, M. E., & Bunnell, B. A. (2016). The Effects of Endocrine Disruptors on Mesenchymal Stem Cells. In Stem Cells in Toxicology and Medicine (pp. 196-237). wiley. https://doi.org/10.1002/9781119135449.ch11