The Effects of Endocrine Disruptors on Mesenchymal Stem Cells

Marjorie E. Bateman; Amy L. Strong; John McLachlan; Matthew E. Burow; Bruce A. Bunnell

doi:10.1002/9781119135449.ch11

The Effects of Endocrine Disruptors on Mesenchymal Stem Cells

Marjorie E. Bateman, Amy L. Strong, John McLachlan, Matthew E. Burow, Bruce A. Bunnell

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Endocrine disrupting compounds (EDCs) are a growing area of research in toxicology as these compounds impact human health and disease. One explanation for the rapid rise in prevalence of diseases such as obesity and diabetes mellitus is the exposure to EDCs. EDCs may have the capacity to disrupt vital aspects of multipotent mesenchymal stromal cell or mesenchymal stem cell (MSC) and MSC lineage cell function in the body, including the ability of MSCs to proliferate, to differentiate, and to maintain body homeostasis. Salient information regarding MSC characterization, differentiation, function, and aging will be addressed. This chapter will cover effects of EDCs including organophosphate pesticides, DDT, alkylphenols, bisphenol A (BPA), polychlorinated biphenyls (PCBs), and phthalates on MSCs and the adipocytic and osteoblastic lineage of MSCs in addition to general molecular effects of these compounds. The effects of EDCs on MSCs, particularly the adipocytic lineage of MSCs, may explain the EDC role in inducing development of chronic diseases such as obesity and diabetes mellitus.

Original language	English
Title of host publication	Stem Cells in Toxicology and Medicine
Publisher	wiley
Pages	196-237
Number of pages	42
ISBN (Electronic)	9781119135449
ISBN (Print)	9781119135418
DOIs	https://doi.org/10.1002/9781119135449.ch11
State	Published - 28 Dec 2016

Keywords

Adipogenesis
Bisphenol A
DDT
Endocrine disruptors
Mesenchymal stem cells
Nonylphenol
Obesity
Octylphenol
Organophosphates
Phthalic acids
Polychlorinated biphenyls

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10.1002/9781119135449.ch11

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abstract = "Endocrine disrupting compounds (EDCs) are a growing area of research in toxicology as these compounds impact human health and disease. One explanation for the rapid rise in prevalence of diseases such as obesity and diabetes mellitus is the exposure to EDCs. EDCs may have the capacity to disrupt vital aspects of multipotent mesenchymal stromal cell or mesenchymal stem cell (MSC) and MSC lineage cell function in the body, including the ability of MSCs to proliferate, to differentiate, and to maintain body homeostasis. Salient information regarding MSC characterization, differentiation, function, and aging will be addressed. This chapter will cover effects of EDCs including organophosphate pesticides, DDT, alkylphenols, bisphenol A (BPA), polychlorinated biphenyls (PCBs), and phthalates on MSCs and the adipocytic and osteoblastic lineage of MSCs in addition to general molecular effects of these compounds. The effects of EDCs on MSCs, particularly the adipocytic lineage of MSCs, may explain the EDC role in inducing development of chronic diseases such as obesity and diabetes mellitus.",

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AU - McLachlan, John

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AU - Bunnell, Bruce A.

PY - 2016/12/28

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N2 - Endocrine disrupting compounds (EDCs) are a growing area of research in toxicology as these compounds impact human health and disease. One explanation for the rapid rise in prevalence of diseases such as obesity and diabetes mellitus is the exposure to EDCs. EDCs may have the capacity to disrupt vital aspects of multipotent mesenchymal stromal cell or mesenchymal stem cell (MSC) and MSC lineage cell function in the body, including the ability of MSCs to proliferate, to differentiate, and to maintain body homeostasis. Salient information regarding MSC characterization, differentiation, function, and aging will be addressed. This chapter will cover effects of EDCs including organophosphate pesticides, DDT, alkylphenols, bisphenol A (BPA), polychlorinated biphenyls (PCBs), and phthalates on MSCs and the adipocytic and osteoblastic lineage of MSCs in addition to general molecular effects of these compounds. The effects of EDCs on MSCs, particularly the adipocytic lineage of MSCs, may explain the EDC role in inducing development of chronic diseases such as obesity and diabetes mellitus.

AB - Endocrine disrupting compounds (EDCs) are a growing area of research in toxicology as these compounds impact human health and disease. One explanation for the rapid rise in prevalence of diseases such as obesity and diabetes mellitus is the exposure to EDCs. EDCs may have the capacity to disrupt vital aspects of multipotent mesenchymal stromal cell or mesenchymal stem cell (MSC) and MSC lineage cell function in the body, including the ability of MSCs to proliferate, to differentiate, and to maintain body homeostasis. Salient information regarding MSC characterization, differentiation, function, and aging will be addressed. This chapter will cover effects of EDCs including organophosphate pesticides, DDT, alkylphenols, bisphenol A (BPA), polychlorinated biphenyls (PCBs), and phthalates on MSCs and the adipocytic and osteoblastic lineage of MSCs in addition to general molecular effects of these compounds. The effects of EDCs on MSCs, particularly the adipocytic lineage of MSCs, may explain the EDC role in inducing development of chronic diseases such as obesity and diabetes mellitus.

KW - Adipogenesis

KW - Bisphenol A

KW - DDT

KW - Endocrine disruptors

KW - Mesenchymal stem cells

KW - Nonylphenol

KW - Obesity

KW - Octylphenol

KW - Organophosphates

KW - Phthalic acids

KW - Polychlorinated biphenyls

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BT - Stem Cells in Toxicology and Medicine

PB - wiley

ER -

The Effects of Endocrine Disruptors on Mesenchymal Stem Cells

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Keywords

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