TY - JOUR
T1 - The effects of endocrine disruptors on adipogenesis and osteogenesis in mesenchymal stem cells
T2 - A review
AU - Bateman, Marjorie E.
AU - Strong, Amy L.
AU - McLachlan, John A.
AU - Burow, Matthew E.
AU - Bunnell, Bruce A.
N1 - Publisher Copyright:
© 2017 Bateman, Strong, McLachlan, Burow and Bunnell.
PY - 2017
Y1 - 2017
N2 - Endocrine-disrupting chemicals (EDCs) are prevalent in the environment, and epidemiologic studies have suggested that human exposure is linked to chronic diseases, such as obesity and diabetes. In vitro experiments have further demonstrated that EDCs promote changes in mesenchymal stem cells (MSCs), leading to increases in adipogenic differentiation, decreases in osteogenic differentiation, activation of pro-inflammatory cytokines, increases in oxidative stress, and epigenetic changes. Studies have also shown alteration in trophic factor production, differentiation ability, and immunomodulatory capacity of MSCs, which have significant implications to the current studies exploring MSCs for tissue engineering and regenerative medicine applications and the treatment of inflammatory conditions. Thus, the consideration of the effects of EDCs on MSCs is vital when determining potential therapeutic uses of MSCs, as increased exposure to EDCs may cause MSCs to be less effective therapeutically. This review focuses on the adipogenic and osteogenic differentiation effects of EDCs as these are most relevant to the therapeutic uses of MSCs in tissue engineering, regenerative medicine, and inflammatory conditions. This review will highlight the effects of EDCs, including organophosphates, plasticizers, industrial surfactants, coolants, and lubricants, on MSC biology.
AB - Endocrine-disrupting chemicals (EDCs) are prevalent in the environment, and epidemiologic studies have suggested that human exposure is linked to chronic diseases, such as obesity and diabetes. In vitro experiments have further demonstrated that EDCs promote changes in mesenchymal stem cells (MSCs), leading to increases in adipogenic differentiation, decreases in osteogenic differentiation, activation of pro-inflammatory cytokines, increases in oxidative stress, and epigenetic changes. Studies have also shown alteration in trophic factor production, differentiation ability, and immunomodulatory capacity of MSCs, which have significant implications to the current studies exploring MSCs for tissue engineering and regenerative medicine applications and the treatment of inflammatory conditions. Thus, the consideration of the effects of EDCs on MSCs is vital when determining potential therapeutic uses of MSCs, as increased exposure to EDCs may cause MSCs to be less effective therapeutically. This review focuses on the adipogenic and osteogenic differentiation effects of EDCs as these are most relevant to the therapeutic uses of MSCs in tissue engineering, regenerative medicine, and inflammatory conditions. This review will highlight the effects of EDCs, including organophosphates, plasticizers, industrial surfactants, coolants, and lubricants, on MSC biology.
KW - Adipogenesis
KW - Endocrine disruptors
KW - Immunomodulation
KW - Mesenchymal stem cells
KW - Tissue engineering
KW - Tissue scaffolds
UR - http://www.scopus.com/inward/record.url?scp=85011878131&partnerID=8YFLogxK
U2 - 10.3389/fendo.2016.00171
DO - 10.3389/fendo.2016.00171
M3 - Review article
AN - SCOPUS:85011878131
SN - 1664-2392
VL - 7
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
IS - JAN
M1 - 171
ER -