TY - JOUR
T1 - The effects of Asian population substructure on Y STR forensic analyses
AU - Budowle, Bruce
AU - Ge, Jianye
AU - Low, Joyce
AU - Lai, Crystal
AU - Yee, Wong Hang
AU - Law, Grace
AU - Tan, Wai Fun
AU - Chang, Yuet Meng
AU - Perumal, Revathi
AU - Keat, Phoon Yoong
AU - Mizuno, Natsuko
AU - Kasai, Kentaro
AU - Sekiguchi, Kazumasa
AU - Chakraborty, Ranajit
PY - 2009/3
Y1 - 2009/3
N2 - A total of 3046 males of Chinese, Malay, Thai, Japanese, and Indian population affinity were previously typed for the Y STR loci DYS19, DYS385 (counted as two loci), DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS456, DYS458, DYS635, DYS448, and Y GATA H4 using the AmpFlSTR® Yfiler™ kit. These samples were assessed for population genetic parameters that impact forensic statistical calculations. All population samples were highly polymorphic for the 16 Y STR markers with the marker DYS385 being the most polymorphic, because it is comprised of two loci. Most (2677 out of a total of 2806 distinct haplotypes) of the 16 marker haplotypes observed in the sample populations were represented only once in the data set. Haplotype diversities were greater than 99.57% for the Chinese, Malay, Thai, Japanese, and Indian sample populations. For the Y STR markers, population substructure correction was considered when calculating the rarity of a Y STR profile. An FST value, rather than a RST value, is more appropriate under a forensic model. Because the FST values are very small within the Asian populations, the estimate of the rarity of a haplotype comprised of 10-16 markers does not need substructure correction. However haplotypes with fewer markers may require FST corrections when calculating the rarity of the profile.
AB - A total of 3046 males of Chinese, Malay, Thai, Japanese, and Indian population affinity were previously typed for the Y STR loci DYS19, DYS385 (counted as two loci), DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS456, DYS458, DYS635, DYS448, and Y GATA H4 using the AmpFlSTR® Yfiler™ kit. These samples were assessed for population genetic parameters that impact forensic statistical calculations. All population samples were highly polymorphic for the 16 Y STR markers with the marker DYS385 being the most polymorphic, because it is comprised of two loci. Most (2677 out of a total of 2806 distinct haplotypes) of the 16 marker haplotypes observed in the sample populations were represented only once in the data set. Haplotype diversities were greater than 99.57% for the Chinese, Malay, Thai, Japanese, and Indian sample populations. For the Y STR markers, population substructure correction was considered when calculating the rarity of a Y STR profile. An FST value, rather than a RST value, is more appropriate under a forensic model. Because the FST values are very small within the Asian populations, the estimate of the rarity of a haplotype comprised of 10-16 markers does not need substructure correction. However haplotypes with fewer markers may require FST corrections when calculating the rarity of the profile.
KW - DNA typing
KW - F
KW - Forensic science
KW - Haplotype
KW - Partial profile
KW - Population substructure
KW - Statistics
KW - Y chromosome
KW - Y short tandem repeat (Y STR)
UR - http://www.scopus.com/inward/record.url?scp=58749106582&partnerID=8YFLogxK
U2 - 10.1016/j.legalmed.2008.08.003
DO - 10.1016/j.legalmed.2008.08.003
M3 - Article
C2 - 19038565
AN - SCOPUS:58749106582
SN - 1344-6223
VL - 11
SP - 64
EP - 69
JO - Legal Medicine
JF - Legal Medicine
IS - 2
ER -