The effect of some cigarette smoke constituents and other compounds on the metabolism of benzo(a)pyrene in rabbit lung 9000 g supernatant

A. Hulshoff, William Charles Lubawy, H. B. Kostenbauder

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

1. The inhibitory effects, of a number of compounds, on the formation of two groups of benzo(a)pyrene metabolites in rabbit lung homogenates (9000 g supernatant) have been investigated. 2. The inhibitors comprised two groups: those inhibiting primarily benzo(a)-pyrene hydroxylase activity, and those inhibiting the activity of the epoxide-metabolizing enzymes as well as hydroxylase activity. Phenol, 1-naphthol, nicotine and acetone belong to the former group; naphthalene, anthracene and chlorpromazine to the latter group. 3. The most active inhibitors also caused a significant decrease in the amount of benzo(a)pyrene bound covalently to tissue macromolecules.

Original languageEnglish
Pages (from-to)711-717
Number of pages7
JournalXenobiotica
Volume8
Issue number11
DOIs
StatePublished - 1 Jan 1978

Fingerprint

Benzo(a)pyrene
Metabolism
Smoke
Tobacco Products
Benzopyrene Hydroxylase
Rabbits
Lung
Epoxy Compounds
Chlorpromazine
Metabolites
Acetone
Mixed Function Oxygenases
Phenol
Macromolecules
Nicotine
Tissue
Enzymes
1-naphthol
naphthalene
anthracene

Cite this

Hulshoff, A. ; Lubawy, William Charles ; Kostenbauder, H. B. / The effect of some cigarette smoke constituents and other compounds on the metabolism of benzo(a)pyrene in rabbit lung 9000 g supernatant. In: Xenobiotica. 1978 ; Vol. 8, No. 11. pp. 711-717.
@article{74792db8f2df4d4ba3bad9c37f9287e9,
title = "The effect of some cigarette smoke constituents and other compounds on the metabolism of benzo(a)pyrene in rabbit lung 9000 g supernatant",
abstract = "1. The inhibitory effects, of a number of compounds, on the formation of two groups of benzo(a)pyrene metabolites in rabbit lung homogenates (9000 g supernatant) have been investigated. 2. The inhibitors comprised two groups: those inhibiting primarily benzo(a)-pyrene hydroxylase activity, and those inhibiting the activity of the epoxide-metabolizing enzymes as well as hydroxylase activity. Phenol, 1-naphthol, nicotine and acetone belong to the former group; naphthalene, anthracene and chlorpromazine to the latter group. 3. The most active inhibitors also caused a significant decrease in the amount of benzo(a)pyrene bound covalently to tissue macromolecules.",
author = "A. Hulshoff and Lubawy, {William Charles} and Kostenbauder, {H. B.}",
year = "1978",
month = "1",
day = "1",
doi = "10.3109/00498257809069583",
language = "English",
volume = "8",
pages = "711--717",
journal = "Xenobiotica",
issn = "0049-8254",
publisher = "Informa Healthcare",
number = "11",

}

The effect of some cigarette smoke constituents and other compounds on the metabolism of benzo(a)pyrene in rabbit lung 9000 g supernatant. / Hulshoff, A.; Lubawy, William Charles; Kostenbauder, H. B.

In: Xenobiotica, Vol. 8, No. 11, 01.01.1978, p. 711-717.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The effect of some cigarette smoke constituents and other compounds on the metabolism of benzo(a)pyrene in rabbit lung 9000 g supernatant

AU - Hulshoff, A.

AU - Lubawy, William Charles

AU - Kostenbauder, H. B.

PY - 1978/1/1

Y1 - 1978/1/1

N2 - 1. The inhibitory effects, of a number of compounds, on the formation of two groups of benzo(a)pyrene metabolites in rabbit lung homogenates (9000 g supernatant) have been investigated. 2. The inhibitors comprised two groups: those inhibiting primarily benzo(a)-pyrene hydroxylase activity, and those inhibiting the activity of the epoxide-metabolizing enzymes as well as hydroxylase activity. Phenol, 1-naphthol, nicotine and acetone belong to the former group; naphthalene, anthracene and chlorpromazine to the latter group. 3. The most active inhibitors also caused a significant decrease in the amount of benzo(a)pyrene bound covalently to tissue macromolecules.

AB - 1. The inhibitory effects, of a number of compounds, on the formation of two groups of benzo(a)pyrene metabolites in rabbit lung homogenates (9000 g supernatant) have been investigated. 2. The inhibitors comprised two groups: those inhibiting primarily benzo(a)-pyrene hydroxylase activity, and those inhibiting the activity of the epoxide-metabolizing enzymes as well as hydroxylase activity. Phenol, 1-naphthol, nicotine and acetone belong to the former group; naphthalene, anthracene and chlorpromazine to the latter group. 3. The most active inhibitors also caused a significant decrease in the amount of benzo(a)pyrene bound covalently to tissue macromolecules.

UR - http://www.scopus.com/inward/record.url?scp=0018178822&partnerID=8YFLogxK

U2 - 10.3109/00498257809069583

DO - 10.3109/00498257809069583

M3 - Article

VL - 8

SP - 711

EP - 717

JO - Xenobiotica

JF - Xenobiotica

SN - 0049-8254

IS - 11

ER -