The effect of some cigarette smoke constituents and other compounds on the metabolism of benzo(a)pyrene in rabbit lung 9000 g supernatant

A. Hulshoff; W. C. Lubawy; H. B. Kostenbauder

doi:10.3109/00498257809069583

The effect of some cigarette smoke constituents and other compounds on the metabolism of benzo(a)pyrene in rabbit lung 9000 g supernatant

A. Hulshoff, W. C. Lubawy, H. B. Kostenbauder

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

1. The inhibitory effects, of a number of compounds, on the formation of two groups of benzo(a)pyrene metabolites in rabbit lung homogenates (9000 g supernatant) have been investigated. 2. The inhibitors comprised two groups: those inhibiting primarily benzo(a)-pyrene hydroxylase activity, and those inhibiting the activity of the epoxide-metabolizing enzymes as well as hydroxylase activity. Phenol, 1-naphthol, nicotine and acetone belong to the former group; naphthalene, anthracene and chlorpromazine to the latter group. 3. The most active inhibitors also caused a significant decrease in the amount of benzo(a)pyrene bound covalently to tissue macromolecules.

Original language	English
Pages (from-to)	711-717
Number of pages	7
Journal	Xenobiotica
Volume	8
Issue number	11
DOIs	https://doi.org/10.3109/00498257809069583
State	Published - 1978

Access to Document

10.3109/00498257809069583

Cite this

@article{74792db8f2df4d4ba3bad9c37f9287e9,

title = "The effect of some cigarette smoke constituents and other compounds on the metabolism of benzo(a)pyrene in rabbit lung 9000 g supernatant",

abstract = "1. The inhibitory effects, of a number of compounds, on the formation of two groups of benzo(a)pyrene metabolites in rabbit lung homogenates (9000 g supernatant) have been investigated. 2. The inhibitors comprised two groups: those inhibiting primarily benzo(a)-pyrene hydroxylase activity, and those inhibiting the activity of the epoxide-metabolizing enzymes as well as hydroxylase activity. Phenol, 1-naphthol, nicotine and acetone belong to the former group; naphthalene, anthracene and chlorpromazine to the latter group. 3. The most active inhibitors also caused a significant decrease in the amount of benzo(a)pyrene bound covalently to tissue macromolecules.",

author = "A. Hulshoff and Lubawy, {W. C.} and Kostenbauder, {H. B.}",

note = "Funding Information: This investigation was supported by the University of Kentucky Tobacco and Health Research Institute Projects No. 033 and 098.",

year = "1978",

doi = "10.3109/00498257809069583",

language = "English",

volume = "8",

pages = "711--717",

journal = "Xenobiotica",

issn = "0049-8254",

publisher = "Informa Healthcare",

number = "11",

}

TY - JOUR

T1 - The effect of some cigarette smoke constituents and other compounds on the metabolism of benzo(a)pyrene in rabbit lung 9000 g supernatant

AU - Hulshoff, A.

AU - Lubawy, W. C.

AU - Kostenbauder, H. B.

N1 - Funding Information: This investigation was supported by the University of Kentucky Tobacco and Health Research Institute Projects No. 033 and 098.

PY - 1978

Y1 - 1978

N2 - 1. The inhibitory effects, of a number of compounds, on the formation of two groups of benzo(a)pyrene metabolites in rabbit lung homogenates (9000 g supernatant) have been investigated. 2. The inhibitors comprised two groups: those inhibiting primarily benzo(a)-pyrene hydroxylase activity, and those inhibiting the activity of the epoxide-metabolizing enzymes as well as hydroxylase activity. Phenol, 1-naphthol, nicotine and acetone belong to the former group; naphthalene, anthracene and chlorpromazine to the latter group. 3. The most active inhibitors also caused a significant decrease in the amount of benzo(a)pyrene bound covalently to tissue macromolecules.

AB - 1. The inhibitory effects, of a number of compounds, on the formation of two groups of benzo(a)pyrene metabolites in rabbit lung homogenates (9000 g supernatant) have been investigated. 2. The inhibitors comprised two groups: those inhibiting primarily benzo(a)-pyrene hydroxylase activity, and those inhibiting the activity of the epoxide-metabolizing enzymes as well as hydroxylase activity. Phenol, 1-naphthol, nicotine and acetone belong to the former group; naphthalene, anthracene and chlorpromazine to the latter group. 3. The most active inhibitors also caused a significant decrease in the amount of benzo(a)pyrene bound covalently to tissue macromolecules.

UR - http://www.scopus.com/inward/record.url?scp=0018178822&partnerID=8YFLogxK

U2 - 10.3109/00498257809069583

DO - 10.3109/00498257809069583

M3 - Article

C2 - 726515

AN - SCOPUS:0018178822

SN - 0049-8254

VL - 8

SP - 711

EP - 717

JO - Xenobiotica

JF - Xenobiotica

IS - 11

ER -

The effect of some cigarette smoke constituents and other compounds on the metabolism of benzo(a)pyrene in rabbit lung 9000 g supernatant

Abstract

Access to Document

Other files and links

Fingerprint

Cite this