The effect of intermittent hypoxia training on migraine: A randomized controlled trial

Xiao Bao, Howe Liu, Hui Yu Liu, Ying Long, Jie Wen Tan, Zhi Min Zhu

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To study the effect of intermittent hypoxia training (IHT) for migraine. Design: A single-blind, randomized controlled trial. All participants were recruited from a rehabilitation department in an acute university-affiliated hospital. Methods: Participants with migraines were randomly assigned to two groups (IHT group and control group). The Migraine Disability Assessment (MIDAS), Visual Analog Scale (VAS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Vascular endothelial growth factor (VEGF), calcitonin gene related peptide (CGRP) and cerebrovascular hemodynamic parameters were collected at baseline and end of the 8th week. The attack frequencies of migraines were evaluated at 3 months. Results: Among the 48 subjects, five males and forty-three females, the ages ranged from 19 to 53 years old (mean ± SD = 31.3±7.78). MIDAS, SF-36, VAS, BAI, BDI, VEGF, CGRP and cerebrovascular hemodynamic parameters were improved after IHT intervention. There were significant differences between IHT group and the control group in MIDAS, SF-36, VAS, BAI, BDI, VEGF, CGRP and cerebrovascular hemodynamic parameters at the end of the 8thweeks (P<0.05). Attack frequencies were improved within 3 months after IH training intervention (P<0.01), but not in the control group (P>0.05). No adverse events occurred during the study. Conclusion: IHT could improve migraines after intervention up to three months. IHT could be an effective method for relieving a migraine.

Original languageEnglish
Pages (from-to)4059-4065
Number of pages7
JournalAmerican Journal of Translational Research
Volume12
Issue number7
StatePublished - 2020

Keywords

  • Intermittent hypoxia training
  • Migraine

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