The effect of changes in cardiac output on middle cerebral artery mean blood velocity at rest and during exercise

Shigehiko Ogoh, Matthew Brothers, Quinton Barnes, Wendy L. Eubank, Megan N. Hawkins, Sushimita Purkayastha, Albert Yurvati, Peter B. Raven

Research output: Contribution to journalArticleResearchpeer-review

172 Citations (Scopus)

Abstract

We examined the relationship between changes in cardiac output (Q̇) and middle cerebral artery mean blood velocity (MCA Vmean) in seven healthy volunteer men at rest and during 50% maximal oxygen uptake steady-state submaximal cycling exercise. Reductions in Q̇were accomplished using lower body negative pressure (LBNP), while increases in Q̇were accomplished using infusions of 25% human serum albumin. Heart rate (HR), arterial blood pressure and MCA Vmean were continuously recorded. At each stage of LBNP and albumin infusion Q̇was measured using an acetylene rebreathing technique. Arterial blood samples were analysed for partial pressure of carbon dioxide tension (Pa,CO2). During exercise HR and Q̇were increased above rest (P < 0.001), while neither MCA Vmean nor Pa,CO2 was altered (P > 0.05). The MCA Vmean and Q̇were linearly related at rest (P < 0.001) and during exercise (P = 0.035). The slope of the regression relationship between MCA Vmean and Q̇at rest was greater (P = 0.035) than during exercise. In addition, the phase and gain between MCA Vmean and mean arterial pressure in the low frequency range were not altered from rest to exercise indicating that the cerebral autoregulation was maintained. These data suggest that the Q̇associated with the changes in central blood volume influence the MCA Vmean at rest and during exercise and its regulation is independent of cerebral autoregulation. It appears that the exercise induced sympathoexcitation and the change in the distribution of Q̇between the cerebral and the systemic circulation modifies the relationship between MCA Vmean and Q̇.

Original languageEnglish
Pages (from-to)697-704
Number of pages8
JournalJournal of Physiology
Volume569
Issue number2
DOIs
StatePublished - 1 Dec 2005

Fingerprint

Middle Cerebral Artery
Cardiac Output
Exercise
Lower Body Negative Pressure
Cerebrovascular Circulation
Arterial Pressure
Homeostasis
Heart Rate
Acetylene
Partial Pressure
Blood Volume
Carbon Dioxide
Serum Albumin
Albumins
Healthy Volunteers
Oxygen

Cite this

Ogoh, S., Brothers, M., Barnes, Q., Eubank, W. L., Hawkins, M. N., Purkayastha, S., ... Raven, P. B. (2005). The effect of changes in cardiac output on middle cerebral artery mean blood velocity at rest and during exercise. Journal of Physiology, 569(2), 697-704. https://doi.org/10.1113/jphysiol.2005.095836
Ogoh, Shigehiko ; Brothers, Matthew ; Barnes, Quinton ; Eubank, Wendy L. ; Hawkins, Megan N. ; Purkayastha, Sushimita ; Yurvati, Albert ; Raven, Peter B. / The effect of changes in cardiac output on middle cerebral artery mean blood velocity at rest and during exercise. In: Journal of Physiology. 2005 ; Vol. 569, No. 2. pp. 697-704.
@article{78c664dff03749b9bd371bc24200a1ad,
title = "The effect of changes in cardiac output on middle cerebral artery mean blood velocity at rest and during exercise",
abstract = "We examined the relationship between changes in cardiac output (Q̇) and middle cerebral artery mean blood velocity (MCA Vmean) in seven healthy volunteer men at rest and during 50{\%} maximal oxygen uptake steady-state submaximal cycling exercise. Reductions in Q̇were accomplished using lower body negative pressure (LBNP), while increases in Q̇were accomplished using infusions of 25{\%} human serum albumin. Heart rate (HR), arterial blood pressure and MCA Vmean were continuously recorded. At each stage of LBNP and albumin infusion Q̇was measured using an acetylene rebreathing technique. Arterial blood samples were analysed for partial pressure of carbon dioxide tension (Pa,CO2). During exercise HR and Q̇were increased above rest (P < 0.001), while neither MCA Vmean nor Pa,CO2 was altered (P > 0.05). The MCA Vmean and Q̇were linearly related at rest (P < 0.001) and during exercise (P = 0.035). The slope of the regression relationship between MCA Vmean and Q̇at rest was greater (P = 0.035) than during exercise. In addition, the phase and gain between MCA Vmean and mean arterial pressure in the low frequency range were not altered from rest to exercise indicating that the cerebral autoregulation was maintained. These data suggest that the Q̇associated with the changes in central blood volume influence the MCA Vmean at rest and during exercise and its regulation is independent of cerebral autoregulation. It appears that the exercise induced sympathoexcitation and the change in the distribution of Q̇between the cerebral and the systemic circulation modifies the relationship between MCA Vmean and Q̇.",
author = "Shigehiko Ogoh and Matthew Brothers and Quinton Barnes and Eubank, {Wendy L.} and Hawkins, {Megan N.} and Sushimita Purkayastha and Albert Yurvati and Raven, {Peter B.}",
year = "2005",
month = "12",
day = "1",
doi = "10.1113/jphysiol.2005.095836",
language = "English",
volume = "569",
pages = "697--704",
journal = "Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "2",

}

Ogoh, S, Brothers, M, Barnes, Q, Eubank, WL, Hawkins, MN, Purkayastha, S, Yurvati, A & Raven, PB 2005, 'The effect of changes in cardiac output on middle cerebral artery mean blood velocity at rest and during exercise', Journal of Physiology, vol. 569, no. 2, pp. 697-704. https://doi.org/10.1113/jphysiol.2005.095836

The effect of changes in cardiac output on middle cerebral artery mean blood velocity at rest and during exercise. / Ogoh, Shigehiko; Brothers, Matthew; Barnes, Quinton; Eubank, Wendy L.; Hawkins, Megan N.; Purkayastha, Sushimita; Yurvati, Albert; Raven, Peter B.

In: Journal of Physiology, Vol. 569, No. 2, 01.12.2005, p. 697-704.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The effect of changes in cardiac output on middle cerebral artery mean blood velocity at rest and during exercise

AU - Ogoh, Shigehiko

AU - Brothers, Matthew

AU - Barnes, Quinton

AU - Eubank, Wendy L.

AU - Hawkins, Megan N.

AU - Purkayastha, Sushimita

AU - Yurvati, Albert

AU - Raven, Peter B.

PY - 2005/12/1

Y1 - 2005/12/1

N2 - We examined the relationship between changes in cardiac output (Q̇) and middle cerebral artery mean blood velocity (MCA Vmean) in seven healthy volunteer men at rest and during 50% maximal oxygen uptake steady-state submaximal cycling exercise. Reductions in Q̇were accomplished using lower body negative pressure (LBNP), while increases in Q̇were accomplished using infusions of 25% human serum albumin. Heart rate (HR), arterial blood pressure and MCA Vmean were continuously recorded. At each stage of LBNP and albumin infusion Q̇was measured using an acetylene rebreathing technique. Arterial blood samples were analysed for partial pressure of carbon dioxide tension (Pa,CO2). During exercise HR and Q̇were increased above rest (P < 0.001), while neither MCA Vmean nor Pa,CO2 was altered (P > 0.05). The MCA Vmean and Q̇were linearly related at rest (P < 0.001) and during exercise (P = 0.035). The slope of the regression relationship between MCA Vmean and Q̇at rest was greater (P = 0.035) than during exercise. In addition, the phase and gain between MCA Vmean and mean arterial pressure in the low frequency range were not altered from rest to exercise indicating that the cerebral autoregulation was maintained. These data suggest that the Q̇associated with the changes in central blood volume influence the MCA Vmean at rest and during exercise and its regulation is independent of cerebral autoregulation. It appears that the exercise induced sympathoexcitation and the change in the distribution of Q̇between the cerebral and the systemic circulation modifies the relationship between MCA Vmean and Q̇.

AB - We examined the relationship between changes in cardiac output (Q̇) and middle cerebral artery mean blood velocity (MCA Vmean) in seven healthy volunteer men at rest and during 50% maximal oxygen uptake steady-state submaximal cycling exercise. Reductions in Q̇were accomplished using lower body negative pressure (LBNP), while increases in Q̇were accomplished using infusions of 25% human serum albumin. Heart rate (HR), arterial blood pressure and MCA Vmean were continuously recorded. At each stage of LBNP and albumin infusion Q̇was measured using an acetylene rebreathing technique. Arterial blood samples were analysed for partial pressure of carbon dioxide tension (Pa,CO2). During exercise HR and Q̇were increased above rest (P < 0.001), while neither MCA Vmean nor Pa,CO2 was altered (P > 0.05). The MCA Vmean and Q̇were linearly related at rest (P < 0.001) and during exercise (P = 0.035). The slope of the regression relationship between MCA Vmean and Q̇at rest was greater (P = 0.035) than during exercise. In addition, the phase and gain between MCA Vmean and mean arterial pressure in the low frequency range were not altered from rest to exercise indicating that the cerebral autoregulation was maintained. These data suggest that the Q̇associated with the changes in central blood volume influence the MCA Vmean at rest and during exercise and its regulation is independent of cerebral autoregulation. It appears that the exercise induced sympathoexcitation and the change in the distribution of Q̇between the cerebral and the systemic circulation modifies the relationship between MCA Vmean and Q̇.

UR - http://www.scopus.com/inward/record.url?scp=29244485576&partnerID=8YFLogxK

U2 - 10.1113/jphysiol.2005.095836

DO - 10.1113/jphysiol.2005.095836

M3 - Article

VL - 569

SP - 697

EP - 704

JO - Journal of Physiology

JF - Journal of Physiology

SN - 0022-3751

IS - 2

ER -