The Effect of Captopril on the Oxidation of Plasma Lipoproteins

Michael B. Clearfield, Nam Lee, Larry Armstrong, Peggy DeFazio, B. J. Kudchodkar, Andras G. Lacko

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Abstract

Abstract: The antihypertensive drug captopril was found to inhibit the oxidation of low density lipoproteins by copper in a dose dependent manner in vitro. Up to 65% inhibition of oxidation was observed at the concentration of 100 μg/ml of captopril. During subsequent studies with patients, captopril protected low density lipoproteins against oxidation slightly better than enalapril, although this difference was not statistically significant. Captopril had no effect on the levels of Lp(a) as compared to the levels established during enalapril treatment. 1994 Nordic Pharmacological Society

Original languageEnglish
Pages (from-to)218-221
Number of pages4
JournalPharmacology & Toxicology
Volume75
Issue number3-4
DOIs
StatePublished - 1 Jan 1994

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    Clearfield, M. B., Lee, N., Armstrong, L., DeFazio, P., Kudchodkar, B. J., & Lacko, A. G. (1994). The Effect of Captopril on the Oxidation of Plasma Lipoproteins. Pharmacology & Toxicology, 75(3-4), 218-221. https://doi.org/10.1111/j.1600-0773.1994.tb00350.x