The effect of antiretrovirals on Plasmodium falciparum liver stages

Charlotte V. Hobbs, Patricia De La Vega, Scott Robert Penzak, Jillian Van Vliet, Urszula Krzych, Photini Sinnis, William Borkowsky, Patrick E. Duffy

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

HIV and malaria overlap geographically, but the full impact of different antiretrovirals on malaria remains poorly understood. We examined the anti-malarial activity of the HIV protease inhibitors lopinavir and saquinavir and the non-nucleoside reverse transcriptase inhibitor nevirapine on Plasmodium falciparum liver stages. Our results demonstrate that the HIV PI lopinavir inhibits liver stage parasites at clinically relevant concentrations, that is, at drug levels achieved in HIV-infected patients on standard dosing regimens. Because drugs that inhibit liver stages target parasites when they are present in lower numbers, these results might have implications for eradication efforts.

Original languageEnglish
Pages (from-to)1674-1677
Number of pages4
JournalAIDS
Volume27
Issue number10
DOIs
StatePublished - 19 Jun 2013

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Plasmodium falciparum
Lopinavir
HIV
Malaria
Liver
Parasites
Saquinavir
HIV Protease Inhibitors
Nevirapine
Reverse Transcriptase Inhibitors
Antimalarials
Pharmaceutical Preparations

Cite this

Hobbs, C. V., De La Vega, P., Penzak, S. R., Van Vliet, J., Krzych, U., Sinnis, P., ... Duffy, P. E. (2013). The effect of antiretrovirals on Plasmodium falciparum liver stages. AIDS, 27(10), 1674-1677. https://doi.org/10.1097/QAD.0b013e3283621dd4
Hobbs, Charlotte V. ; De La Vega, Patricia ; Penzak, Scott Robert ; Van Vliet, Jillian ; Krzych, Urszula ; Sinnis, Photini ; Borkowsky, William ; Duffy, Patrick E. / The effect of antiretrovirals on Plasmodium falciparum liver stages. In: AIDS. 2013 ; Vol. 27, No. 10. pp. 1674-1677.
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Hobbs, CV, De La Vega, P, Penzak, SR, Van Vliet, J, Krzych, U, Sinnis, P, Borkowsky, W & Duffy, PE 2013, 'The effect of antiretrovirals on Plasmodium falciparum liver stages', AIDS, vol. 27, no. 10, pp. 1674-1677. https://doi.org/10.1097/QAD.0b013e3283621dd4

The effect of antiretrovirals on Plasmodium falciparum liver stages. / Hobbs, Charlotte V.; De La Vega, Patricia; Penzak, Scott Robert; Van Vliet, Jillian; Krzych, Urszula; Sinnis, Photini; Borkowsky, William; Duffy, Patrick E.

In: AIDS, Vol. 27, No. 10, 19.06.2013, p. 1674-1677.

Research output: Contribution to journalArticle

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AU - Duffy, Patrick E.

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Hobbs CV, De La Vega P, Penzak SR, Van Vliet J, Krzych U, Sinnis P et al. The effect of antiretrovirals on Plasmodium falciparum liver stages. AIDS. 2013 Jun 19;27(10):1674-1677. https://doi.org/10.1097/QAD.0b013e3283621dd4