TY - JOUR
T1 - The effect of age, sex and strains on the performance and outcome in animal models of stroke
AU - Zhang, Hongxia
AU - Lin, Siyang
AU - Chen, Xudong
AU - Gu, Lei
AU - Zhu, Xiaohong
AU - Zhang, Yinuo
AU - Reyes, Kassandra
AU - Wang, Brian
AU - Jin, Kunlin
N1 - Funding Information:
American Heart Association Predoctoral Fellowship (USA) to Hongxia Zhang (18PRE34020126).
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2019/7
Y1 - 2019/7
N2 - Stroke is one of the leading causes of death worldwide, and the majority of cerebral stroke is caused by occlusion of cerebral circulation, which eventually leads to brain infarction. Although stroke occurs mainly in the aged population, most animal models for experimental stroke in vivo almost universally rely on young-adult rodents for the evaluation of neuropathological, neurological, or behavioral outcomes after stroke due to their greater availability, lower cost, and fewer health problems. However, it is well established that aged animals differ from young animals in terms of physiology, neurochemistry, and behavior. Stroke-induced changes are more pronounced with advancing age. Therefore, the overlooked role of age in animal models of stroke could have an impact on data quality and hinder the translation of rodent models to humans. In addition to aging, other factors also influence functional performance after ischemic stroke. In this article, we summarize the differences between young and aged animals, the impact of age, sex and animal strains on performance and outcome in animal models of stroke and emphasize age as a key factor in preclinical stroke studies.
AB - Stroke is one of the leading causes of death worldwide, and the majority of cerebral stroke is caused by occlusion of cerebral circulation, which eventually leads to brain infarction. Although stroke occurs mainly in the aged population, most animal models for experimental stroke in vivo almost universally rely on young-adult rodents for the evaluation of neuropathological, neurological, or behavioral outcomes after stroke due to their greater availability, lower cost, and fewer health problems. However, it is well established that aged animals differ from young animals in terms of physiology, neurochemistry, and behavior. Stroke-induced changes are more pronounced with advancing age. Therefore, the overlooked role of age in animal models of stroke could have an impact on data quality and hinder the translation of rodent models to humans. In addition to aging, other factors also influence functional performance after ischemic stroke. In this article, we summarize the differences between young and aged animals, the impact of age, sex and animal strains on performance and outcome in animal models of stroke and emphasize age as a key factor in preclinical stroke studies.
KW - Aging
KW - Ischemia stroke
KW - Lifespan
KW - Preclinical study
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=85054422301&partnerID=8YFLogxK
U2 - 10.1016/j.neuint.2018.10.005
DO - 10.1016/j.neuint.2018.10.005
M3 - Review article
C2 - 30291954
AN - SCOPUS:85054422301
SN - 0197-0186
VL - 127
SP - 2
EP - 11
JO - Neurochemistry International
JF - Neurochemistry International
ER -