The distribution of the HLA-DQα alleles and genotypes in the Finnish population as determined by the use of DNA amplification and allele specific oligonucleotides

A. Sajantilala, M. Ström, Bruce Budowle, P. J. Tienari, C. Ehnholm, L. Peltonen

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Allele and genotype frequencies for the HLA-130α locus were determined for use in forensic analyses and paternity tests in Finland. The polymerase chain reaction (PCR) and the reverse dot blot format were employed to detect 6 different HLA-DQα alleles. All 6 HLA-DQα alleles were detected among the 112 unrelated individuals with allele frequencies ranging from 5.8% to 32.6%. The distribution of the observed genotypes is in Hardy-Weinberg equilibrium. Additionally, this Finnish population sample is statistically similar to 2 other Caucasian sample populations. The power of discrimination of this system in the Finnish population sample is 0.92, suggesting this method may prove suitable for identification purposes.

Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalInternational Journal of Legal Medicine
Volume104
Issue number4
DOIs
StatePublished - 1 Jul 1991

Keywords

  • Allele specific oligonucleotides
  • Finnish population
  • HLADQα
  • Polymerase chain reaction (PCR)
  • Population genetics

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