The complement component C4 in black Americans with Type 1 (insulin-dependent) diabetes mellitus

B. Budowle, J. M. Roseman, R. C.P. Go, B. O. Barger, R. T. Acton

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The complement component C4 variants C4A4, C4B 4 and C4B QO were found to be significantly increased in 64 black patients with Type 1 (insulin-dependent) diabetes compared with 169 black control subjects, yielding relative risks of 3.3, 2.9 and 3.4, respectively. The increased frequencies of C4B 4 and C4B QO in black Type 1 diabetic patients are similar to those found in Caucasoid Type 1 diabetic patients. The data suggest that Type 1 diabetes in black Americans may be partially due to admixture of genes from whites.

Original languageEnglish
Pages (from-to)166-168
Number of pages3
JournalDiabetologia
Volume26
Issue number2
DOIs
StatePublished - Feb 1984

Keywords

  • Complement component C4
  • Type 1 diabetes mellitus
  • black Americans

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