The cholinergic potential, the vagus nerve and challenges in treatment of traumatic brain injury

Victor V. Uteshev; Olli Tenovuo; Nikhil Gaidhani

doi:10.2174/1381612822666160127111630

The cholinergic potential, the vagus nerve and challenges in treatment of traumatic brain injury

Victor V. Uteshev, Olli Tenovuo, Nikhil Gaidhani

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Existing treatments of traumatic brain injury (TBI) have failed to reverse tremendous losses in productivity, independence and overall quality of life among TBI victims and therefore, cannot be viewed as sufficient. Although there is no shortage of promising basic concepts that may translate to efficacious therapies after TBI, the accumulated knowledge has yet to deliver treatments that adequately meet clinical and social demands. In this article, we discuss novel concepts, recent advances and accompanying challenges in developing cholinergic and related therapies after TBI.

Original language	English
Pages (from-to)	2083-2092
Number of pages	10
Journal	Current Pharmaceutical Design
Volume	22
Issue number	14
DOIs	https://doi.org/10.2174/1381612822666160127111630
State	Published - 1 Apr 2016

Keywords

Acetylcholine
Brain
Cholinergic
Immune
Inflammatory
Injury
Nicotinic
Stimulation
Trauma
Vagal
Vagus

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KW - Inflammatory

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KW - Nicotinic

KW - Stimulation

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The cholinergic potential, the vagus nerve and challenges in treatment of traumatic brain injury

Abstract

Keywords

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