The cholinergic potential, the vagus nerve and challenges in treatment of traumatic brain injury

Victor V. Uteshev, Olli Tenovuo, Nikhil Gaidhani

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Existing treatments of traumatic brain injury (TBI) have failed to reverse tremendous losses in productivity, independence and overall quality of life among TBI victims and therefore, cannot be viewed as sufficient. Although there is no shortage of promising basic concepts that may translate to efficacious therapies after TBI, the accumulated knowledge has yet to deliver treatments that adequately meet clinical and social demands. In this article, we discuss novel concepts, recent advances and accompanying challenges in developing cholinergic and related therapies after TBI.

Original languageEnglish
Pages (from-to)2083-2092
Number of pages10
JournalCurrent Pharmaceutical Design
Volume22
Issue number14
DOIs
StatePublished - 1 Apr 2016

Keywords

  • Acetylcholine
  • Brain
  • Cholinergic
  • Immune
  • Inflammatory
  • Injury
  • Nicotinic
  • Stimulation
  • Trauma
  • Vagal
  • Vagus

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