Abstract
The benzodiazepine receptor partial inverse agonist RO 15-3505 was tested for its ability to improve impaired recent memory of aged mice. All mice successfully acquired a learning set for accurate identification of the correct arm of a T-maze and could perform with nearly 100% accuracy after 1-min delays. However, performance of the aged mice approached chance levels after 2-h delays. When injected just before testing on a series of 2-h retention tests, RO 15-3505 (from 2.5-10.0 mg/kg) resulted in a marked improvement of response accuracy. These results confirm the role of benzodiazepine receptor mechanisms in the modulation of memory processes, and suggest that the memory-facilitating effects RO 15-3505 or similar benzodiazepine receptor ligands may be generalized to aged rodents with impaired memory function.
Original language | English |
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Pages (from-to) | 557-560 |
Number of pages | 4 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 51 |
Issue number | 2-3 |
DOIs | |
State | Published - 1995 |
Keywords
- Aging, memory decline
- Alzheimer's disease
- Benzodiazepine antagonist
- Benzodiazepine inverse agonist
- C57BL/6NNia mice
- Flumazenil
- RO 15-3505
- Working memory