The benzodiazepine receptor inverse agonist RO 15-3505 reverses recent memory deficits in aged mice

Michael J. Forster, Paul L. Prather, Semir R. Patel, Harbans Lal

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The benzodiazepine receptor partial inverse agonist RO 15-3505 was tested for its ability to improve impaired recent memory of aged mice. All mice successfully acquired a learning set for accurate identification of the correct arm of a T-maze and could perform with nearly 100% accuracy after 1-min delays. However, performance of the aged mice approached chance levels after 2-h delays. When injected just before testing on a series of 2-h retention tests, RO 15-3505 (from 2.5-10.0 mg/kg) resulted in a marked improvement of response accuracy. These results confirm the role of benzodiazepine receptor mechanisms in the modulation of memory processes, and suggest that the memory-facilitating effects RO 15-3505 or similar benzodiazepine receptor ligands may be generalized to aged rodents with impaired memory function.

Original languageEnglish
Pages (from-to)557-560
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume51
Issue number2-3
DOIs
StatePublished - 1 Jan 1995

Keywords

  • Aging, memory decline
  • Alzheimer's disease
  • Benzodiazepine antagonist
  • Benzodiazepine inverse agonist
  • C57BL/6NNia mice
  • Flumazenil
  • RO 15-3505
  • Working memory

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