@article{e32d47082fd64455af62c7e316b75d36,
title = "The association between antagonist hamstring coactivation and episodes of knee joint shifting and buckling",
abstract = "Hamstring coactivation during quadriceps activation is necessary to counteract the quadriceps pull on the tibia, but coactivation can be elevated with symptomatic knee osteoarthritis (OA). To guide rehabilitation to attenuate risk for mobility limitations and falls, this study evaluated whether higher antagonistic open kinetic chain hamstring coactivation is associated with knee joint buckling (sudden loss of support) and shifting (a sensation that the knee might give way). Design: At baseline, median hamstring coactivation was assessed during maximal isokinetic knee extensor strength testing and at baseline and 24-month follow-up, knee buckling and shifting was self-reported. Associations between tertiles of co-activation and knee (1) buckling, (2) shifting and (3) either buckling or shifting were assessed using logistic regression, adjusted for age, sex, knee OA and pain. Results: 1826 participants (1089 women) were included. Mean ± SD age was 61.7 ± 7.7 years, BMI was 30.3 ± 5.5 kg/m2 and 38.2% of knees had OA. There were no consistent statistically significant associations between hamstring coactivation and ipsilateral prevalent or incident buckling or the combination of buckling and shifting. The odds ratios for incident shifting in the highest in comparison with the lowest tertile of coactivation had similar magnitudes in the combined and medial hamstrings, but only reached statistical significance for lateral hamstring coactivation, OR(95%CI) 1.53 (0.99, 2.36). Conclusions: Hamstring coactivation during an open kinetic chain quadriceps exercise was not consistently associated with prevalent or incident self-reported knee buckling or shifting in older adults with or at risk for knee OA.",
keywords = "Epidemiology, Knee, Muscle activation, Osteoarthritis",
author = "{for the MOST Investigative Group} and Segal, {N. A.} and Nevitt, {M. C.} and Welborn, {R. D.} and Nguyen, {U. S.D.T.} and J. Niu and Lewis, {C. E.} and Felson, {D. T.} and L. Frey-Law",
note = "Funding Information: This study was supported by NIH grants to: Boston University (David Felson, MD – AG18820); University of Iowa (James Torner, PhD – AG18832); University of Alabama at Birmingham (Cora E. Lewis, MD MSPH – AG18947); University of California San Francisco (Michael Nevitt, PhD – AG19069) and a Carver College of Medicine Summer Research Fellowship (T35HL007485-34). The authors have no professional relationships with companies or manufacturers who will benefit from the results of the present study. Funding Information: The study sponsor had no involvement in the study design, collection, analysis and interpretation of data, writing of the manuscript and decision to submit the manuscript for publication. This study was supported by NIH grants to: Boston University (David Felson, MD – AG18820 ); The University of Iowa (James Torner, PhD – AG18832 , Laura Frey Law, PhD – AR056134 , Neil A. Segal T35HL007485); University of Alabama at Birmingham (Cora E. Lewis, MD MSPH – AG18947 ); University of California San Francisco (Michael Nevitt, PhD – AG19069 ). Funding Information: This study was supported by NIH grants to Boston University (David Felson, MD – AG18820); University of Iowa (James Torner, PhD – AG18832); University of Alabama at Birmingham (Cora E. Lewis, MD MSPH – AG18947); University of California San Francisco (Michael Nevitt, PhD – AG19069) and a Carver College of Medicine Summer Research Fellowship (T35HL007485-34). The funding organizations had no role in the data collection, analysis, interpretation or decision to publish this study. Publisher Copyright: {\textcopyright} 2015.",
year = "2015",
month = jul,
day = "1",
doi = "10.1016/j.joca.2015.02.773",
language = "English",
volume = "23",
pages = "1112--1121",
journal = "Osteoarthritis and Cartilage",
issn = "1063-4584",
publisher = "W.B. Saunders Ltd",
number = "7",
}