TY - JOUR
T1 - The assessment of frequency estimates of Hae III-generated VNTR profiles in various reference databases
AU - Budowle, B.
AU - Monson, K. L.
AU - Giusti, A. M.
AU - Brown, B. L.
PY - 1994
Y1 - 1994
N2 - The likelihood of occurrence of 1964 Hae III-generated target DNA profiles was estimated using fixed bin frequencies from various regional and ethnic databases and the multiplication rule. The databases generally were from the following major categories: Black, Caucasian, Hispanic, Oriental, and American Indian. It was found that subdivision, either by ethnic group or by U.S. geographic region, within a major population group did not substantially affect forensic estimates of the likelihood of occurrence of a DNA profile. As expected, the greatest variation in estimates for within-group estimates was among American Indian databases. Because the greatest variation in statistical estimates occurs across-major population groups, in most cases, there will be no unfair bias applying general population database estimates. Therefore, based on empirical data, there is no demonstrable need for using alternate approaches, such as the ceiling approach, to derive statistical estimates. The current practice of using general population databases and the multiplication rule provides valid estimates of the likelihood of occurrence of a DNA profile.
AB - The likelihood of occurrence of 1964 Hae III-generated target DNA profiles was estimated using fixed bin frequencies from various regional and ethnic databases and the multiplication rule. The databases generally were from the following major categories: Black, Caucasian, Hispanic, Oriental, and American Indian. It was found that subdivision, either by ethnic group or by U.S. geographic region, within a major population group did not substantially affect forensic estimates of the likelihood of occurrence of a DNA profile. As expected, the greatest variation in estimates for within-group estimates was among American Indian databases. Because the greatest variation in statistical estimates occurs across-major population groups, in most cases, there will be no unfair bias applying general population database estimates. Therefore, based on empirical data, there is no demonstrable need for using alternate approaches, such as the ceiling approach, to derive statistical estimates. The current practice of using general population databases and the multiplication rule provides valid estimates of the likelihood of occurrence of a DNA profile.
KW - VNTR
KW - allele frequency
KW - pathology and biology
KW - population databases
UR - http://www.scopus.com/inward/record.url?scp=0028674232&partnerID=8YFLogxK
U2 - 10.1520/jfs13605j
DO - 10.1520/jfs13605j
M3 - Article
C2 - 7910844
AN - SCOPUS:0028674232
VL - 39
SP - 319
EP - 352
JO - Journal of forensic sciences
JF - Journal of forensic sciences
SN - 0022-1198
IS - 2
ER -