TY - JOUR
T1 - Thailandepsin A
AU - Wang, Cheng
AU - Cheng, Yi Qiang
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/11
Y1 - 2011/11
N2 - Thailandepsin A [systematic name: (E)-(1S,5S,6R,9S,20R)-6-[(2S)-butan-2-yl] -5-hydroxy-20-[2-(methylsulfanyl)ethyl]-2-oxa-11,12-dithia-7,19, 22-triazabicyclo-[7.7.6]docosa-15-ene-3,8,18,21-tetraone], C23H 37N3O6S3, is a newly reported [Wang et al. (2011). J. Nat. Prod. doi:10.1021/np200324x] bicyclic depsipeptide that has potent histone deacetyl-ase inhibitory activity and broad-spectrum antiproliferative activity. The absolute configuration of thailandepsin A has been determined from the anomalous dispersion and the stereochemistry of all chiral C atoms. Intramolecular N - H⋯O and N - H⋯S hydrogen bonds occur. Intermolecular N - H⋯O and O - H⋯O hydrogen bonds are observed in the crystal structure.
AB - Thailandepsin A [systematic name: (E)-(1S,5S,6R,9S,20R)-6-[(2S)-butan-2-yl] -5-hydroxy-20-[2-(methylsulfanyl)ethyl]-2-oxa-11,12-dithia-7,19, 22-triazabicyclo-[7.7.6]docosa-15-ene-3,8,18,21-tetraone], C23H 37N3O6S3, is a newly reported [Wang et al. (2011). J. Nat. Prod. doi:10.1021/np200324x] bicyclic depsipeptide that has potent histone deacetyl-ase inhibitory activity and broad-spectrum antiproliferative activity. The absolute configuration of thailandepsin A has been determined from the anomalous dispersion and the stereochemistry of all chiral C atoms. Intramolecular N - H⋯O and N - H⋯S hydrogen bonds occur. Intermolecular N - H⋯O and O - H⋯O hydrogen bonds are observed in the crystal structure.
UR - http://www.scopus.com/inward/record.url?scp=84455182892&partnerID=8YFLogxK
U2 - 10.1107/S1600536811041390
DO - 10.1107/S1600536811041390
M3 - Article
C2 - 22219976
AN - SCOPUS:84455182892
VL - 67
SP - o2948-o2949
JO - Acta Crystallographica Section E: Structure Reports Online
JF - Acta Crystallographica Section E: Structure Reports Online
SN - 1600-5368
IS - 11
ER -