Thailandepsin A

Cheng Wang; Yi Qiang Cheng

doi:10.1107/S1600536811041390

Thailandepsin A

Cheng Wang, Yi Qiang Cheng

Research output: Contribution to journal › Article

5 Scopus citations

Abstract

Thailandepsin A [systematic name: (E)-(1S,5S,6R,9S,20R)-6-[(2S)-butan-2-yl] -5-hydroxy-20-[2-(methylsulfanyl)ethyl]-2-oxa-11,12-dithia-7,19, 22-triazabicyclo-[7.7.6]docosa-15-ene-3,8,18,21-tetraone], C₂₃H ₃₇N₃O₆S₃, is a newly reported [Wang et al. (2011). J. Nat. Prod. doi:10.1021/np200324x] bicyclic depsipeptide that has potent histone deacetyl-ase inhibitory activity and broad-spectrum antiproliferative activity. The absolute configuration of thailandepsin A has been determined from the anomalous dispersion and the stereochemistry of all chiral C atoms. Intramolecular N - H⋯O and N - H⋯S hydrogen bonds occur. Intermolecular N - H⋯O and O - H⋯O hydrogen bonds are observed in the crystal structure.

Original language	English
Pages (from-to)	o2948-o2949
Journal	Acta Crystallographica Section E: Structure Reports Online
Volume	67
Issue number	11
DOIs	https://doi.org/10.1107/S1600536811041390
Publication status	Published - 1 Nov 2011

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Wang, C., & Cheng, Y. Q. (2011). Thailandepsin A. Acta Crystallographica Section E: Structure Reports Online, 67(11), o2948-o2949. https://doi.org/10.1107/S1600536811041390

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title = "Thailandepsin A",

abstract = "Thailandepsin A [systematic name: (E)-(1S,5S,6R,9S,20R)-6-[(2S)-butan-2-yl] -5-hydroxy-20-[2-(methylsulfanyl)ethyl]-2-oxa-11,12-dithia-7,19, 22-triazabicyclo-[7.7.6]docosa-15-ene-3,8,18,21-tetraone], C23H 37N3O6S3, is a newly reported [Wang et al. (2011). J. Nat. Prod. doi:10.1021/np200324x] bicyclic depsipeptide that has potent histone deacetyl-ase inhibitory activity and broad-spectrum antiproliferative activity. The absolute configuration of thailandepsin A has been determined from the anomalous dispersion and the stereochemistry of all chiral C atoms. Intramolecular N - H⋯O and N - H⋯S hydrogen bonds occur. Intermolecular N - H⋯O and O - H⋯O hydrogen bonds are observed in the crystal structure.",

author = "Cheng Wang and Cheng, {Yi Qiang}",

year = "2011",

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N2 - Thailandepsin A [systematic name: (E)-(1S,5S,6R,9S,20R)-6-[(2S)-butan-2-yl] -5-hydroxy-20-[2-(methylsulfanyl)ethyl]-2-oxa-11,12-dithia-7,19, 22-triazabicyclo-[7.7.6]docosa-15-ene-3,8,18,21-tetraone], C23H 37N3O6S3, is a newly reported [Wang et al. (2011). J. Nat. Prod. doi:10.1021/np200324x] bicyclic depsipeptide that has potent histone deacetyl-ase inhibitory activity and broad-spectrum antiproliferative activity. The absolute configuration of thailandepsin A has been determined from the anomalous dispersion and the stereochemistry of all chiral C atoms. Intramolecular N - H⋯O and N - H⋯S hydrogen bonds occur. Intermolecular N - H⋯O and O - H⋯O hydrogen bonds are observed in the crystal structure.

AB - Thailandepsin A [systematic name: (E)-(1S,5S,6R,9S,20R)-6-[(2S)-butan-2-yl] -5-hydroxy-20-[2-(methylsulfanyl)ethyl]-2-oxa-11,12-dithia-7,19, 22-triazabicyclo-[7.7.6]docosa-15-ene-3,8,18,21-tetraone], C23H 37N3O6S3, is a newly reported [Wang et al. (2011). J. Nat. Prod. doi:10.1021/np200324x] bicyclic depsipeptide that has potent histone deacetyl-ase inhibitory activity and broad-spectrum antiproliferative activity. The absolute configuration of thailandepsin A has been determined from the anomalous dispersion and the stereochemistry of all chiral C atoms. Intramolecular N - H⋯O and N - H⋯S hydrogen bonds occur. Intermolecular N - H⋯O and O - H⋯O hydrogen bonds are observed in the crystal structure.

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