Thailandepsin A [systematic name: (E)-(1S,5S,6R,9S,20R)-6-[(2S)-butan-2-yl] -5-hydroxy-20-[2-(methylsulfanyl)ethyl]-2-oxa-11,12-dithia-7,19, 22-triazabicyclo-[7.7.6]docosa-15-ene-3,8,18,21-tetraone], C23H 37N3O6S3, is a newly reported [Wang et al. (2011). J. Nat. Prod. doi:10.1021/np200324x] bicyclic depsipeptide that has potent histone deacetyl-ase inhibitory activity and broad-spectrum antiproliferative activity. The absolute configuration of thailandepsin A has been determined from the anomalous dispersion and the stereochemistry of all chiral C atoms. Intramolecular N - H⋯O and N - H⋯S hydrogen bonds occur. Intermolecular N - H⋯O and O - H⋯O hydrogen bonds are observed in the crystal structure.
|Journal||Acta Crystallographica Section E: Structure Reports Online|
|State||Published - Nov 2011|